Distribution of ACE2, CD147, CD26, and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors

Background Morbidity and mortality from COVID‐19 caused by novel coronavirus SARS‐CoV‐2 is accelerating worldwide, and novel clinical presentations of COVID‐19 are often reported. The range of human cells and tissues targeted by SARS‐CoV‐2, its potential receptors and associated regulating factors a...

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Published inAllergy (Copenhagen) Vol. 75; no. 11; pp. 2829 - 2845
Main Authors Radzikowska, Urszula, Ding, Mei, Tan, Ge, Zhakparov, Damir, Peng, Yaqi, Wawrzyniak, Paulina, Wang, Ming, Li, Shuo, Morita, Hideaki, Altunbulakli, Can, Reiger, Matthias, Neumann, Avidan U., Lunjani, Nonhlanhla, Traidl‐Hoffmann, Claudia, Nadeau, Kari C., O’Mahony, Liam, Akdis, Cezmi, Sokolowska, Milena
Format Journal Article
LanguageEnglish
Published Denmark Blackwell Publishing Ltd 01.11.2020
John Wiley and Sons Inc
Subjects
ACE2
Adolescent
Adult
Age
Age Factors
Aged
Alveoli
Angiotensin-converting enzyme 2
Angiotensin-Converting Enzyme 2 - genetics
Angiotensin-Converting Enzyme 2 - immunology
Asthma
Asthma - epidemiology
Asthma - genetics
Asthma - immunology
Atopic dermatitis
Basigin - genetics
Basigin - immunology
Biopsy
Bronchus
CD147 antigen
CD4 antigen
CD8 antigen
Child
Child, Preschool
Children
Chronic Disease - epidemiology
Chronic obstructive pulmonary disease
Comorbidity
COPD
COVID-19
COVID-19 - epidemiology
COVID-19 - genetics
COVID-19 - immunology
COVID‐19 children
Dipeptidyl Peptidase 4 - genetics
Dipeptidyl Peptidase 4 - immunology
Dipeptidyl-peptidase IV
Epithelial cells
Epithelium
Female
Gender
Gene expression
Gene Expression - genetics
Humans
Hypertension
Hypertension - epidemiology
Hypertension - genetics
Hypertension - immunology
Immunity, Innate - immunology
Infant
Leukocytes (mononuclear)
Leukocytes (neutrophilic)
Lymphocytes B
Lymphocytes T
Male
Middle Aged
Monocytes
Morbidity
Obesity
Obesity - epidemiology
Obesity - genetics
Obesity - immunology
Original
ORIGINAL ARTICLES
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - genetics
Pulmonary Disease, Chronic Obstructive - immunology
Ribonucleic acid
Risk Factors
RNA
SARS receptor
SARS-CoV-2 - genetics
SARS-CoV-2 - immunology
Severe acute respiratory syndrome coronavirus 2
Skin diseases
Young Adult
COVID-19
COVID-19 children
asthma
hypertension
SARS receptor
obesity
COPD
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Abstract Background Morbidity and mortality from COVID‐19 caused by novel coronavirus SARS‐CoV‐2 is accelerating worldwide, and novel clinical presentations of COVID‐19 are often reported. The range of human cells and tissues targeted by SARS‐CoV‐2, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS‐CoV‐2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID‐19. Methods We performed RNA sequencing and explored available RNA‐Seq databases to study gene expression and co‐expression of ACE2, CD147 (BSG), and CD26 (DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4+ and CD8+ T cells, B cells, and plasmablasts. We analyzed the material from healthy children and adults, and from adults in relation to their disease or COVID‐19 risk factor status. Results ACE2 and TMPRSS2 were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (BSG), cyclophilins (PPIA andPPIB), CD26 (DPP4), and related molecules were expressed in both epithelium and in immune cells. We also observed a distinct age‐related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2‐ and CD147‐related genes in the bronchial biopsy, BAL, or blood. Additionally, CD147‐related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of CD147‐related genes in the lesional skin of patients with atopic dermatitis. Conclusions Our data suggest different receptor repertoire potentially involved in the SARS‐CoV‐2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID‐19 morbidity and severity patterns. ACE2 and TMPRSS2 expression is unique for the epithelial barrier sites, whereas CD147, cyclophilins, and CD26 are expressed in both, epithelial and immune cells. Age is a factor associated with the differential expression profiles of ACE2‐, CD147‐ and CD26‐related genes in the PBMCs and naive CD4+ T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender generally lead to the higher expression of ACE2‐ and CD147‐related genes in the bronchial biopsy, BAL or blood. Abbreviations: ACE2, angiotensin‐converting enzyme 2; AD, atopic dermatitis; BAL, bronchoalveolar lavage; COPD, chronic obstructive pulmonary disease; CypA, cyclophilin A; CypB, cyclophilin B; GLUT1, glucose transporter 1; ILC, innate lymphoid cell; MCTs, monocarboxylate transporters; NF‐ATs, nuclear factor of activated T cells; PBMCs, peripheral blood mononuclear cells; SARS‐CoV‐2; severe acute respiratory syndrome coronavirus 2; SLC6A19, sodium‐dependent neutral amino acid transporter B(0)AT1; S100A9, protein S100‐A9; TMPRSS2, transmembrane protease serine.
AbstractList Morbidity and mortality from COVID-19 caused by novel coronavirus SARS-CoV-2 is accelerating worldwide, and novel clinical presentations of COVID-19 are often reported. The range of human cells and tissues targeted by SARS-CoV-2, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS-CoV-2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID-19.BACKGROUNDMorbidity and mortality from COVID-19 caused by novel coronavirus SARS-CoV-2 is accelerating worldwide, and novel clinical presentations of COVID-19 are often reported. The range of human cells and tissues targeted by SARS-CoV-2, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS-CoV-2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID-19.We performed RNA sequencing and explored available RNA-Seq databases to study gene expression and co-expression of ACE2, CD147 (BSG), and CD26 (DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4+ and CD8+ T cells, B cells, and plasmablasts. We analyzed the material from healthy children and adults, and from adults in relation to their disease or COVID-19 risk factor status.METHODSWe performed RNA sequencing and explored available RNA-Seq databases to study gene expression and co-expression of ACE2, CD147 (BSG), and CD26 (DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4+ and CD8+ T cells, B cells, and plasmablasts. We analyzed the material from healthy children and adults, and from adults in relation to their disease or COVID-19 risk factor status.ACE2 and TMPRSS2 were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (BSG), cyclophilins (PPIA andPPIB), CD26 (DPP4), and related molecules were expressed in both epithelium and in immune cells. We also observed a distinct age-related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2- and CD147-related genes in the bronchial biopsy, BAL, or blood. Additionally, CD147-related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of CD147-related genes in the lesional skin of patients with atopic dermatitis.RESULTSACE2 and TMPRSS2 were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (BSG), cyclophilins (PPIA andPPIB), CD26 (DPP4), and related molecules were expressed in both epithelium and in immune cells. We also observed a distinct age-related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2- and CD147-related genes in the bronchial biopsy, BAL, or blood. Additionally, CD147-related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of CD147-related genes in the lesional skin of patients with atopic dermatitis.Our data suggest different receptor repertoire potentially involved in the SARS-CoV-2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID-19 morbidity and severity patterns.CONCLUSIONSOur data suggest different receptor repertoire potentially involved in the SARS-CoV-2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID-19 morbidity and severity patterns.
Morbidity and mortality from COVID-19 caused by novel coronavirus SARS-CoV-2 is accelerating worldwide, and novel clinical presentations of COVID-19 are often reported. The range of human cells and tissues targeted by SARS-CoV-2, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS-CoV-2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID-19. We performed RNA sequencing and explored available RNA-Seq databases to study gene expression and co-expression of ACE2, CD147 (BSG), and CD26 (DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4 and CD8 T cells, B cells, and plasmablasts. We analyzed the material from healthy children and adults, and from adults in relation to their disease or COVID-19 risk factor status. ACE2 and TMPRSS2 were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (BSG), cyclophilins (PPIA andPPIB), CD26 (DPP4), and related molecules were expressed in both epithelium and in immune cells. We also observed a distinct age-related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2- and CD147-related genes in the bronchial biopsy, BAL, or blood. Additionally, CD147-related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of CD147-related genes in the lesional skin of patients with atopic dermatitis. Our data suggest different receptor repertoire potentially involved in the SARS-CoV-2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID-19 morbidity and severity patterns.
ACE2 and TMPRSS2 expression is unique for the epithelial barrier sites, whereas CD147, cyclophilins, and CD26 are expressed in both, epithelial and immune cells. Age is a factor associated with the differential expression profiles of ACE2‐, CD147‐ and CD26‐related genes in the PBMCs and naive CD4 + T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender generally lead to the higher expression of ACE2‐ and CD147‐related genes in the bronchial biopsy, BAL or blood. Abbreviations: ACE2, angiotensin‐converting enzyme 2; AD, atopic dermatitis; BAL, bronchoalveolar lavage; COPD, chronic obstructive pulmonary disease; CypA, cyclophilin A; CypB, cyclophilin B; GLUT1, glucose transporter 1; ILC, innate lymphoid cell; MCTs, monocarboxylate transporters; NF‐ATs, nuclear factor of activated T cells; PBMCs, peripheral blood mononuclear cells; SARS‐CoV‐2; severe acute respiratory syndrome coronavirus 2; SLC6A19, sodium‐dependent neutral amino acid transporter B(0)AT1; S100A9, protein S100‐A9; TMPRSS2, transmembrane protease serine.
BackgroundMorbidity and mortality from COVID‐19 caused by novel coronavirus SARS‐CoV‐2 is accelerating worldwide, and novel clinical presentations of COVID‐19 are often reported. The range of human cells and tissues targeted by SARS‐CoV‐2, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS‐CoV‐2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID‐19.MethodsWe performed RNA sequencing and explored available RNA‐Seq databases to study gene expression and co‐expression of ACE2, CD147 (BSG), and CD26 (DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4+ and CD8+ T cells, B cells, and plasmablasts. We analyzed the material from healthy children and adults, and from adults in relation to their disease or COVID‐19 risk factor status.ResultsACE2 and TMPRSS2 were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (BSG), cyclophilins (PPIA andPPIB), CD26 (DPP4), and related molecules were expressed in both epithelium and in immune cells. We also observed a distinct age‐related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2‐ and CD147‐related genes in the bronchial biopsy, BAL, or blood. Additionally, CD147‐related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of CD147‐related genes in the lesional skin of patients with atopic dermatitis.ConclusionsOur data suggest different receptor repertoire potentially involved in the SARS‐CoV‐2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID‐19 morbidity and severity patterns.
Background Morbidity and mortality from COVID‐19 caused by novel coronavirus SARS‐CoV‐2 is accelerating worldwide, and novel clinical presentations of COVID‐19 are often reported. The range of human cells and tissues targeted by SARS‐CoV‐2, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS‐CoV‐2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID‐19. Methods We performed RNA sequencing and explored available RNA‐Seq databases to study gene expression and co‐expression of ACE2, CD147 (BSG), and CD26 (DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4+ and CD8+ T cells, B cells, and plasmablasts. We analyzed the material from healthy children and adults, and from adults in relation to their disease or COVID‐19 risk factor status. Results ACE2 and TMPRSS2 were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (BSG), cyclophilins (PPIA andPPIB), CD26 (DPP4), and related molecules were expressed in both epithelium and in immune cells. We also observed a distinct age‐related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2‐ and CD147‐related genes in the bronchial biopsy, BAL, or blood. Additionally, CD147‐related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of CD147‐related genes in the lesional skin of patients with atopic dermatitis. Conclusions Our data suggest different receptor repertoire potentially involved in the SARS‐CoV‐2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID‐19 morbidity and severity patterns. ACE2 and TMPRSS2 expression is unique for the epithelial barrier sites, whereas CD147, cyclophilins, and CD26 are expressed in both, epithelial and immune cells. Age is a factor associated with the differential expression profiles of ACE2‐, CD147‐ and CD26‐related genes in the PBMCs and naive CD4+ T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender generally lead to the higher expression of ACE2‐ and CD147‐related genes in the bronchial biopsy, BAL or blood. Abbreviations: ACE2, angiotensin‐converting enzyme 2; AD, atopic dermatitis; BAL, bronchoalveolar lavage; COPD, chronic obstructive pulmonary disease; CypA, cyclophilin A; CypB, cyclophilin B; GLUT1, glucose transporter 1; ILC, innate lymphoid cell; MCTs, monocarboxylate transporters; NF‐ATs, nuclear factor of activated T cells; PBMCs, peripheral blood mononuclear cells; SARS‐CoV‐2; severe acute respiratory syndrome coronavirus 2; SLC6A19, sodium‐dependent neutral amino acid transporter B(0)AT1; S100A9, protein S100‐A9; TMPRSS2, transmembrane protease serine.
Author Radzikowska, Urszula
Tan, Ge
Li, Shuo
Altunbulakli, Can
Reiger, Matthias
Zhakparov, Damir
Ding, Mei
Neumann, Avidan U.
Sokolowska, Milena
Wang, Ming
Wawrzyniak, Paulina
Traidl‐Hoffmann, Claudia
Lunjani, Nonhlanhla
O’Mahony, Liam
Morita, Hideaki
Peng, Yaqi
Nadeau, Kari C.
Akdis, Cezmi
AuthorAffiliation 16 Department of Medicine and School of Microbiology APC Microbiome Ireland National University of Ireland Cork Ireland
12 Chair and Institute of Environmental Medicine UNIKA‐T Technical University of Munich and Helmholtz Zentrum Munchen Augsburg Germany
4 Department of Allergology Zhongnan Hospital of Wuhan University Wuhan China
14 Institute of Experimental Medicine (IEM) Czech Academy of Sciences Prague Czech Republic
1 Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland
10 Department of Cancer Immunology Institute for Cancer Research Oslo University Hospital Oslo Norway
7 Division of Clinical Chemistry and Biochemistry University Children`s Hospital Zurich Zurich Switzerland
5 Functional Genomic Centre Zurich ETH Zurich/University of Zurich Zurich Switzerland
8 Children`s Research Center University Children`s Hospital Zurich Zurich Switzerland
15 Sean N Parker Centre for Allergy and Asthma Research at Stanford University Department of Medicine Stanfo
AuthorAffiliation_xml – name: 14 Institute of Experimental Medicine (IEM) Czech Academy of Sciences Prague Czech Republic
– name: 4 Department of Allergology Zhongnan Hospital of Wuhan University Wuhan China
– name: 8 Children`s Research Center University Children`s Hospital Zurich Zurich Switzerland
– name: 16 Department of Medicine and School of Microbiology APC Microbiome Ireland National University of Ireland Cork Ireland
– name: 12 Chair and Institute of Environmental Medicine UNIKA‐T Technical University of Munich and Helmholtz Zentrum Munchen Augsburg Germany
– name: 15 Sean N Parker Centre for Allergy and Asthma Research at Stanford University Department of Medicine Stanford University School of Medicine Stanford USA
– name: 6 Otorhinolaryngology Hospital The First Affiliated Hospital Sun Yat‐sen University Guangzhou China
– name: 7 Division of Clinical Chemistry and Biochemistry University Children`s Hospital Zurich Zurich Switzerland
– name: 5 Functional Genomic Centre Zurich ETH Zurich/University of Zurich Zurich Switzerland
– name: 2 Christine Kühne – Center for Research and Education (CK‐CARE) Davos Switzerland
– name: 3 Department of Regenerative Medicine and Immune Regulation Medical University of Bialystok Bialystok Poland
– name: 1 Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland
– name: 11 Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development Tokyo Japan
– name: 10 Department of Cancer Immunology Institute for Cancer Research Oslo University Hospital Oslo Norway
– name: 13 Institute of Computational Biology (ICB) Helmholtz Zentrum Munchen Munich Germany
– name: 9 Department of Otolaryngology, Head and Neck Surgery Beijing TongRen Hospital Capital Medical University and the Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China
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  givenname: Urszula
  orcidid: 0000-0002-7341-9764
  surname: Radzikowska
  fullname: Radzikowska, Urszula
  organization: Medical University of Bialystok
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  surname: Ding
  fullname: Ding, Mei
  organization: Zhongnan Hospital of Wuhan University
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  orcidid: 0000-0003-0026-8739
  surname: Tan
  fullname: Tan, Ge
  organization: ETH Zurich/University of Zurich
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  surname: Zhakparov
  fullname: Zhakparov, Damir
  organization: University of Zurich
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  surname: Peng
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  organization: Sun Yat‐sen University
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  surname: Wang
  fullname: Wang, Ming
  organization: Beijing Institute of Otolaryngology
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  organization: Oslo University Hospital
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  surname: Morita
  fullname: Morita, Hideaki
  organization: National Research Institute for Child Health and Development
– sequence: 10
  givenname: Can
  orcidid: 0000-0003-2264-7377
  surname: Altunbulakli
  fullname: Altunbulakli, Can
  organization: Christine Kühne – Center for Research and Education (CK‐CARE)
– sequence: 11
  givenname: Matthias
  surname: Reiger
  fullname: Reiger, Matthias
  organization: Technical University of Munich and Helmholtz Zentrum Munchen
– sequence: 12
  givenname: Avidan U.
  surname: Neumann
  fullname: Neumann, Avidan U.
  organization: Czech Academy of Sciences
– sequence: 13
  givenname: Nonhlanhla
  surname: Lunjani
  fullname: Lunjani, Nonhlanhla
  organization: Christine Kühne – Center for Research and Education (CK‐CARE)
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  givenname: Claudia
  orcidid: 0000-0001-5085-5179
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  organization: Technical University of Munich and Helmholtz Zentrum Munchen
– sequence: 15
  givenname: Kari C.
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  surname: Nadeau
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  organization: Stanford University School of Medicine
– sequence: 16
  givenname: Liam
  orcidid: 0000-0003-4705-3583
  surname: O’Mahony
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  organization: National University of Ireland
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  givenname: Cezmi
  orcidid: 0000-0001-8020-019X
  surname: Akdis
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  organization: Christine Kühne – Center for Research and Education (CK‐CARE)
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  givenname: Milena
  orcidid: 0000-0001-9710-6685
  surname: Sokolowska
  fullname: Sokolowska, Milena
  email: milena.sokolowska@siaf.uzh.ch
  organization: Christine Kühne – Center for Research and Education (CK‐CARE)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32496587$$D View this record in MEDLINE/PubMed
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Issue 11
Keywords COVID-19
COVID-19 children
asthma
hypertension
SARS receptor
obesity
COPD
Language English
License 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
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Notes Urszula Radzikowska and Mei Ding equally contributed.
Abbreviations: AD, Atopic dermatitis; ALI, Air‐liquid interface cultures; BAL, Bronchoalveolar lavage; BMI, Body mass index; COPD, Chronic obstructive pulmonary disease; COVID‐19, Coronavirus disease 2019; DCs , Dendritic cells; HBECs, Human Bronchial Epithelial Cells; HCV, Hepatitis C virus; HIV, Human immunodeficiency virus; ILC, Innate lymphoid cells; MERS‐CoV, Middle East respiratory syndrome‐related coronavirus; MTCs, Monocarboxylate transporters; NFATs, Nuclear Factor of activated T cells; NK cells, Natural killer cells; nsp1; Non‐structural protein 1; PBMCs, Peripheral blood mononuclear cells; pDCs, Plasmacytoid dendritic cells; RNA‐seq, RNA‐sequencing; SARS‐CoV, Severe acute respiratory syndrome coronavirus; SARS‐CoV‐2, Severe acute respiratory syndrome coronavirus 2; Treg, T regulatory cells
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33089902 - Dermatol Ther. 2020 Nov;33(6):e14443
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Snippet Background Morbidity and mortality from COVID‐19 caused by novel coronavirus SARS‐CoV‐2 is accelerating worldwide, and novel clinical presentations of COVID‐19...
Morbidity and mortality from COVID-19 caused by novel coronavirus SARS-CoV-2 is accelerating worldwide, and novel clinical presentations of COVID-19 are often...
BackgroundMorbidity and mortality from COVID‐19 caused by novel coronavirus SARS‐CoV‐2 is accelerating worldwide, and novel clinical presentations of COVID‐19...
ACE2 and TMPRSS2 expression is unique for the epithelial barrier sites, whereas CD147, cyclophilins, and CD26 are expressed in both, epithelial and immune...
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StartPage 2829
SubjectTerms ACE2
Adolescent
Adult
Age
Age Factors
Aged
Alveoli
Angiotensin-converting enzyme 2
Angiotensin-Converting Enzyme 2 - genetics
Angiotensin-Converting Enzyme 2 - immunology
Asthma
Asthma - epidemiology
Asthma - genetics
Asthma - immunology
Atopic dermatitis
Basigin - genetics
Basigin - immunology
Biopsy
Bronchus
CD147 antigen
CD4 antigen
CD8 antigen
Child
Child, Preschool
Children
Chronic Disease - epidemiology
Chronic obstructive pulmonary disease
Comorbidity
COPD
COVID-19
COVID-19 - epidemiology
COVID-19 - genetics
COVID-19 - immunology
COVID‐19 children
Dipeptidyl Peptidase 4 - genetics
Dipeptidyl Peptidase 4 - immunology
Dipeptidyl-peptidase IV
Epithelial cells
Epithelium
Female
Gender
Gene expression
Gene Expression - genetics
Humans
Hypertension
Hypertension - epidemiology
Hypertension - genetics
Hypertension - immunology
Immunity, Innate - immunology
Infant
Leukocytes (mononuclear)
Leukocytes (neutrophilic)
Lymphocytes B
Lymphocytes T
Male
Middle Aged
Monocytes
Morbidity
Obesity
Obesity - epidemiology
Obesity - genetics
Obesity - immunology
Original
ORIGINAL ARTICLES
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - genetics
Pulmonary Disease, Chronic Obstructive - immunology
Ribonucleic acid
Risk Factors
RNA
SARS receptor
SARS-CoV-2 - genetics
SARS-CoV-2 - immunology
Severe acute respiratory syndrome coronavirus 2
Skin diseases
Young Adult
Title Distribution of ACE2, CD147, CD26, and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fall.14429
https://www.ncbi.nlm.nih.gov/pubmed/32496587
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https://www.proquest.com/docview/2409650029
https://pubmed.ncbi.nlm.nih.gov/PMC7300910
Volume 75
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