High‐mobility group box 1 released by autophagic cancer‐associated fibroblasts maintains the stemness of luminal breast cancer cells

• Published in: The Journal of pathology Vol. 243; no. 3; pp. 376 - 389
• Main Authors: Zhao, Xi‐Long, Lin, Yong, Jiang, Jun, Tang, Zhuo, Yang, Shuai, Lu, Lu, Liang, Yan, Liu, Xue, Tan, Jiao, Hu, Xu‐Gang, Niu, Qin, Fu, Wen‐Juan, Yan, Ze‐Xuan, Guo, De‐Yu, Ping, Yi‐Fang, Wang, Ji Ming, Zhang, Xia, Kung, Hsiang‐Fu, Bian, Xiu‐Wu, Yao, Xiao‐Hong
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.11.2017; Wiley Subscription Services, Inc
• Subjects: Aged; Aged, 80 and over; Autophagy; Breast cancer; breast cancer‐initiating cell (BCIC); Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer-Associated Fibroblasts - metabolism; Cancer-Associated Fibroblasts - pathology; cancer‐associated fibroblast (CAF); Cell Line, Tumor; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Female; Fibroblasts; high‐mobility group box 1 (HMGB1); HMGB1 protein; HMGB1 Protein - metabolism; Humans; Immunohistochemistry; Metastases; Microtubule-associated protein 1; Microtubule-Associated Proteins - metabolism; Middle Aged; Mobility; Neoplasm Recurrence, Local - metabolism; Neoplasm Recurrence, Local - pathology; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Phagocytosis; Phagosomes; Stem cells; TLR4 protein; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Toll‐like receptor 4 (TLR4); Tumor Microenvironment - physiology; Tumorigenesis; Tumors; United Kingdom > UK; Ireland; high-mobility group box 1 (HMGB1); breast cancer-initiating cell (BCIC); Toll-like receptor 4 (TLR4); autophagy; cancer-associated fibroblast (CAF)

Cancer stem cells/cancer‐initiating cells (CICs) and their microenvironmental niche play a vital role in malignant tumour recurrence and metastasis. Cancer‐associated fibroblasts (CAFs) are major components of the niche of breast cancer‐initiating cells (BCICs), and their interactions may profoundly...