Inactivation of three emerging viruses – severe acute respiratory syndrome coronavirus, Crimean–Congo haemorrhagic fever virus and Nipah virus – in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light

• Published in: Vox sanguinis Vol. 115; no. 3; pp. 146 - 151
• Main Authors: Eickmann, Markus, Gravemann, Ute, Handke, Wiebke, Tolksdorf, Frank, Reichenberg, Stefan, Müller, Thomas H., Seltsam, Axel
• Format: Journal Article
• Language: English
• Published: England S. Karger AG 01.04.2020; John Wiley and Sons Inc
• Subjects: Coronaviridae; Coronaviruses; Crimean hemorrhagic fever; Deactivation; Fever; Inactivation; Infectivity; Light; Methylene blue; Nipah virus; Original Paper; pathogen inactivation; plasma; platelet concentrates; Platelets; Respiratory diseases; Severe acute respiratory syndrome; Transfusion; Transfusion‐transmitted Disease and its Prevention; ultraviolet light; Ultraviolet radiation; Viral diseases; Viruses; methylene blue; pathogen inactivation; platelet concentrates; plasma; ultraviolet light

Background Emerging viruses like severe acute respiratory syndrome coronavirus (SARS‐CoV), Crimean–Congo haemorrhagic fever virus (CCHFV) and Nipah virus (NiV) have been identified to pose a potential threat to transfusion safety. In this study, the ability of the THERAFLEX UV‐Platelets and THERAFLE...