Long noncoding RNA LINC00152 promotes cell proliferation through competitively binding endogenous miR‐125b with MCL‐1 by regulating mitochondrial apoptosis pathways in ovarian cancer

• Published in: Cancer medicine (Malden, MA) Vol. 7; no. 9; pp. 4530 - 4541
• Main Authors: Chen, Puxiang, Fang, Xiaolin, Xia, Bing, Zhao, Yan, Li, Qiaoyan, Wu, Xiaoying
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.09.2018; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Aged; Apoptosis; Apoptosis - genetics; Biological activity; Cancer Biology; Cell growth; Cell Line, Tumor; Cell Movement; Cell Proliferation; competitive endogenous RNA; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Immunohistochemistry; LINC00152; long noncoding RNA; MCL‐1; MicroRNAs - genetics; Middle Aged; MiR‐125b; Mitochondria; Mitochondria - genetics; Mitochondria - metabolism; mitochondrial apoptosis pathways; Myeloid Cell Leukemia Sequence 1 Protein - genetics; Myeloid Cell Leukemia Sequence 1 Protein - metabolism; Neoplasm Grading; Original Research; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Ribonucleic acid; RNA; RNA Interference; RNA, Long Noncoding - genetics; Signal Transduction; Tumor cell lines; United States > US; China; LINC00152; MiR-125b; competitive endogenous RNA; cell proliferation; mitochondrial apoptosis pathways; ovarian cancer; MCL-1; long noncoding RNA

Recently, an increasing number of studies have focused on the key function of long noncoding RNAs (lncRNAs) in biological activity. Abnormal lncRNA expression was found to relate to the development and pathogenesis of multiple cancers. LncRNA LINC00152 served as an oncogene in multiple cancers; howe...