Pathomechanisms of TDP‐43 in neurodegeneration

• Published in: Journal of neurochemistry Vol. 146; no. 1; pp. 7 - 20
• Main Authors: Gao, Ju, Wang, Luwen, Huntley, Mikayla L., Perry, George, Wang, Xinglong
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.07.2018
• Subjects: Alzheimer's disease; Amyotrophic lateral sclerosis; Degeneration; Deoxyribonucleic acid; DNA; Frontotemporal dementia; frontotemporal lobar degeneration; Glial cells; Huntington's disease; Huntingtons disease; In vivo methods and tests; Medical treatment; Movement disorders; Mutation; Neurodegeneration; Neurodegenerative diseases; Neurological diseases; Neuronal-glial interactions; Neurons; Neurotoxicity; Parkinson's disease; Phosphorylation; Proteins; Structure-function relationships; TDP‐43; Ubiquitination; neurodegeneration; Neurodegenerative diseases; Alzheimer's disease; amyotrophic lateral sclerosis; TDP-43; frontotemporal lobar degeneration

Neurodegeneration, a term that refers to the progressive loss of structure and function of neurons, is a feature of many neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Alzheimer's disease (AD), Parkinson's disease (PD), and...