Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy

• Published in: Immunological reviews Vol. 308; no. 1; pp. 9 - 24
• Main Authors: Ding, Jiahui, Maxwell, Anthony, Adzibolosu, Nicholas, Hu, Anna, You, Yuan, Liao, Aihua, Mor, Gil
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2022
• Subjects: Antiviral Agents; Developmental stages; Female; Fetus; Fetuses; Homeostasis; Humans; Immune response; Immune system; Immunity, Innate; Immunology; Immunoregulation; Interferon; Interferon Type I; interferon‐stimulated genes; ISG; Placenta; Pregnancy; Pregnancy complications; Signal Transduction; Signaling; trophoblast; type I interferon; Viral infections; type I interferon; placenta; interferon-stimulated genes; ISG; trophoblast; pregnancy

Pregnancy is a unique condition where the maternal immune system is continuously adapting in response to the stages of fetal development and signals from the environment. The placenta is a key mediator of the fetal/maternal interaction by providing signals that regulate the function of the maternal...