NMR visibility of deuterium‐labeled liver glycogen in vivo

• Published in: Magnetic resonance in medicine Vol. 86; no. 1; pp. 62 - 68
• Main Authors: De Feyter, Henk M., Thomas, Monique A., Behar, Kevin L., Graaf, Robin A.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2021
• Subjects: Deuterium; DMI; Drinking water; Glucose; Glycogen; Glycogens; In vivo methods and tests; Line spectra; Liver; NMR; Nuclear magnetic resonance; Spectral line width; DMI; deuterium; glycogen

Purpose Deuterium metabolic imaging (DMI) combined with [6,6’‐2H2]‐glucose has the potential to detect glycogen synthesis in the liver. However, the similar chemical shifts of [6,6’‐2H2]‐glucose and [6,6’‐2H2]‐glycogen in the 2H NMR spectrum make unambiguous detection and separation difficult in viv...