NMR visibility of deuterium‐labeled liver glycogen in vivo
Purpose Deuterium metabolic imaging (DMI) combined with [6,6’‐2H2]‐glucose has the potential to detect glycogen synthesis in the liver. However, the similar chemical shifts of [6,6’‐2H2]‐glucose and [6,6’‐2H2]‐glycogen in the 2H NMR spectrum make unambiguous detection and separation difficult in viv...
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| Published in | Magnetic resonance in medicine Vol. 86; no. 1; pp. 62 - 68 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wiley Subscription Services, Inc
01.07.2021
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| Online Access | Get full text |
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| Abstract | Purpose
Deuterium metabolic imaging (DMI) combined with [6,6’‐2H2]‐glucose has the potential to detect glycogen synthesis in the liver. However, the similar chemical shifts of [6,6’‐2H2]‐glucose and [6,6’‐2H2]‐glycogen in the 2H NMR spectrum make unambiguous detection and separation difficult in vivo, in contrast to comparable approaches using 13C MRS. Here the NMR visibility of 2H‐labeled glycogen is investigated to better understand its potential contribution to the observed signal in liver following administration of [6,6’‐2H2]‐glucose.
Methods
Mice were provided drinking water containing 2H‐labeled glucose. High‐resolution NMR analyses was performed of isolated liver glycogen in solution, before and after the addition of the glucose‐releasing enzyme amyloglucosidase.
Results
2H‐labeled glycogen was barely detectable in solution using 2H NMR because of the very short T2 (<2 ms) of 2H‐labeled glycogen, giving a spectral line width that is more than five times as broad as that of 13C‐labeled glycogen (T2 = ~10 ms).
Conclusion
2H‐labeled glycogen is not detectable with 2H MRS(I) under in vivo conditions, leaving 13C MRS as the preferred technique for in vivo detection of glycogen. |
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| AbstractList | Purpose
Deuterium metabolic imaging (DMI) combined with [6,6’‐2H2]‐glucose has the potential to detect glycogen synthesis in the liver. However, the similar chemical shifts of [6,6’‐2H2]‐glucose and [6,6’‐2H2]‐glycogen in the 2H NMR spectrum make unambiguous detection and separation difficult in vivo, in contrast to comparable approaches using 13C MRS. Here the NMR visibility of 2H‐labeled glycogen is investigated to better understand its potential contribution to the observed signal in liver following administration of [6,6’‐2H2]‐glucose.
Methods
Mice were provided drinking water containing 2H‐labeled glucose. High‐resolution NMR analyses was performed of isolated liver glycogen in solution, before and after the addition of the glucose‐releasing enzyme amyloglucosidase.
Results
2H‐labeled glycogen was barely detectable in solution using 2H NMR because of the very short T2 (<2 ms) of 2H‐labeled glycogen, giving a spectral line width that is more than five times as broad as that of 13C‐labeled glycogen (T2 = ~10 ms).
Conclusion
2H‐labeled glycogen is not detectable with 2H MRS(I) under in vivo conditions, leaving 13C MRS as the preferred technique for in vivo detection of glycogen. Deuterium metabolic imaging (DMI) combined with [6,6'-2 H2 ]-glucose has the potential to detect glycogen synthesis in the liver. However, the similar chemical shifts of [6,6'-2 H2 ]-glucose and [6,6'-2 H2 ]-glycogen in the 2 H NMR spectrum make unambiguous detection and separation difficult in vivo, in contrast to comparable approaches using 13 C MRS. Here the NMR visibility of 2 H-labeled glycogen is investigated to better understand its potential contribution to the observed signal in liver following administration of [6,6'-2 H2 ]-glucose.PURPOSEDeuterium metabolic imaging (DMI) combined with [6,6'-2 H2 ]-glucose has the potential to detect glycogen synthesis in the liver. However, the similar chemical shifts of [6,6'-2 H2 ]-glucose and [6,6'-2 H2 ]-glycogen in the 2 H NMR spectrum make unambiguous detection and separation difficult in vivo, in contrast to comparable approaches using 13 C MRS. Here the NMR visibility of 2 H-labeled glycogen is investigated to better understand its potential contribution to the observed signal in liver following administration of [6,6'-2 H2 ]-glucose.Mice were provided drinking water containing 2 H-labeled glucose. High-resolution NMR analyses was performed of isolated liver glycogen in solution, before and after the addition of the glucose-releasing enzyme amyloglucosidase.METHODSMice were provided drinking water containing 2 H-labeled glucose. High-resolution NMR analyses was performed of isolated liver glycogen in solution, before and after the addition of the glucose-releasing enzyme amyloglucosidase.2 H-labeled glycogen was barely detectable in solution using 2 H NMR because of the very short T2 (<2 ms) of 2 H-labeled glycogen, giving a spectral line width that is more than five times as broad as that of 13 C-labeled glycogen (T2 = ~10 ms).RESULTS2 H-labeled glycogen was barely detectable in solution using 2 H NMR because of the very short T2 (<2 ms) of 2 H-labeled glycogen, giving a spectral line width that is more than five times as broad as that of 13 C-labeled glycogen (T2 = ~10 ms).2 H-labeled glycogen is not detectable with 2 H MRS(I) under in vivo conditions, leaving 13 C MRS as the preferred technique for in vivo detection of glycogen.CONCLUSION2 H-labeled glycogen is not detectable with 2 H MRS(I) under in vivo conditions, leaving 13 C MRS as the preferred technique for in vivo detection of glycogen. PurposeDeuterium metabolic imaging (DMI) combined with [6,6’‐2H2]‐glucose has the potential to detect glycogen synthesis in the liver. However, the similar chemical shifts of [6,6’‐2H2]‐glucose and [6,6’‐2H2]‐glycogen in the 2H NMR spectrum make unambiguous detection and separation difficult in vivo, in contrast to comparable approaches using 13C MRS. Here the NMR visibility of 2H‐labeled glycogen is investigated to better understand its potential contribution to the observed signal in liver following administration of [6,6’‐2H2]‐glucose.MethodsMice were provided drinking water containing 2H‐labeled glucose. High‐resolution NMR analyses was performed of isolated liver glycogen in solution, before and after the addition of the glucose‐releasing enzyme amyloglucosidase.Results2H‐labeled glycogen was barely detectable in solution using 2H NMR because of the very short T2 (<2 ms) of 2H‐labeled glycogen, giving a spectral line width that is more than five times as broad as that of 13C‐labeled glycogen (T2 = ~10 ms).Conclusion2H‐labeled glycogen is not detectable with 2H MRS(I) under in vivo conditions, leaving 13C MRS as the preferred technique for in vivo detection of glycogen. Deuterium metabolic imaging (DMI) combined with [6,6'- H ]-glucose has the potential to detect glycogen synthesis in the liver. However, the similar chemical shifts of [6,6'- H ]-glucose and [6,6'- H ]-glycogen in the H NMR spectrum make unambiguous detection and separation difficult in vivo, in contrast to comparable approaches using C MRS. Here the NMR visibility of H-labeled glycogen is investigated to better understand its potential contribution to the observed signal in liver following administration of [6,6'- H ]-glucose. Mice were provided drinking water containing H-labeled glucose. High-resolution NMR analyses was performed of isolated liver glycogen in solution, before and after the addition of the glucose-releasing enzyme amyloglucosidase. H-labeled glycogen was barely detectable in solution using H NMR because of the very short T (<2 ms) of H-labeled glycogen, giving a spectral line width that is more than five times as broad as that of C-labeled glycogen (T = ~10 ms). H-labeled glycogen is not detectable with H MRS(I) under in vivo conditions, leaving C MRS as the preferred technique for in vivo detection of glycogen. |
| Author | De Feyter, Henk M. Graaf, Robin A. Thomas, Monique A. Behar, Kevin L. |
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| Cites_doi | 10.1006/jmra.1996.0110 10.1021/bi00481a009 10.1002/mrm.1910310518 10.1056/NEJM199001253220403 10.2337/db09-0226 10.1126/science.7292005 10.1038/s41366-020-0533-7 10.1126/sciadv.aat7314 10.1021/bi00274a015 10.1109/42.75611 10.1021/jp963338h 10.1021/ja00184a013 10.3389/fphy.2017.00021 10.1148/radiol.2019191242 10.1016/0008-6215(91)80001-4 10.1074/jbc.R117.802843 10.1177/0271678X17706444 10.1002/mrm.1910310602 |
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Deuterium metabolic imaging (DMI) combined with [6,6’‐2H2]‐glucose has the potential to detect glycogen synthesis in the liver. However, the similar... Deuterium metabolic imaging (DMI) combined with [6,6'- H ]-glucose has the potential to detect glycogen synthesis in the liver. However, the similar chemical... PurposeDeuterium metabolic imaging (DMI) combined with [6,6’‐2H2]‐glucose has the potential to detect glycogen synthesis in the liver. However, the similar... Deuterium metabolic imaging (DMI) combined with [6,6'-2 H2 ]-glucose has the potential to detect glycogen synthesis in the liver. However, the similar chemical... |
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| SubjectTerms | Deuterium DMI Drinking water Glucose Glycogen Glycogens In vivo methods and tests Line spectra Liver NMR Nuclear magnetic resonance Spectral line width |
| Title | NMR visibility of deuterium‐labeled liver glycogen in vivo |
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