Partially impaired functional connectivity states between right anterior insula and default mode network in autism spectrum disorder

• Published in: Human brain mapping Vol. 40; no. 4; pp. 1264 - 1275
• Main Authors: Guo, Xiaonan, Duan, Xujun, Suckling, John, Chen, Heng, Liao, Wei, Cui, Qian, Chen, Huafu
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2019
• Subjects: Adolescent; Autism; autism spectrum disorder; Autism Spectrum Disorder - physiopathology; Brain Mapping - methods; Cerebral Cortex - physiopathology; Child; Clustering; Cognitive ability; Cortex (cingulate); Cortex (temporal); Decoding; default mode network; dynamic functional connectivity; Functional magnetic resonance imaging; Humans; Image Processing, Computer-Assisted - methods; Information processing; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Multivariate analysis; Neural Pathways - physiopathology; Neuroimaging; Prefrontal cortex; Rest - physiology; resting‐state functional magnetic resonance imaging; right anterior insula; state; Variance analysis; resting-state functional magnetic resonance imaging; dynamic functional connectivity; right anterior insula; state; autism spectrum disorder; default mode network

Time‐invariant resting‐state functional connectivity studies have illuminated the crucial role of the right anterior insula (rAI) in prominent social impairments of autism spectrum disorder (ASD). However, a recent dynamic connectivity study demonstrated that rather than being stationary, functional...