Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects: A cross‐over study

• Published in: Clinical and translational science Vol. 14; no. 6; pp. 2408 - 2419
• Main Authors: Kuhlmann, Ida, Nøddebo Nyrup, Amanda, Bjerregaard Stage, Tore, Hougaard Christensen, Mette Marie, Korshøj Bergmann, Troels, Damkier, Per, Nielsen, Flemming, Højlund, Kurt, Brøsen, Kim
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.11.2021; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Algorithms; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - pharmacokinetics; Antidiabetics; Catheters; Codeine; Codeine - administration & dosage; Cross-Over Studies; CYP2D6 protein; Cytochrome P450; Drug dosages; Drug interaction; Drug interactions; Glucose; Health care; Healthy Volunteers; Humans; Intravenous administration; Liquid chromatography; Mass spectroscopy; Metformin; Morphine; Morphine - administration & dosage; Morphine - pharmacokinetics; Oral administration; Pharmacokinetics; Pharmacy; Plasma; Plasma levels; Urine; Young Adult; Denmark

The aim of the study was to investigate if there is a clinically relevant drug interaction between metformin and codeine. Volunteers were randomized to receive on four separate occasions: (A) orally administered metformin (1 g), (B) intravenously administered metformin (0.5 g), (C) five doses of tab...