Impact of Allograft Injury Time of Onset on the Development of Chronic Lung Allograft Dysfunction After Lung Transplantation

• Published in: American journal of transplantation Vol. 17; no. 5; pp. 1294 - 1303
• Main Authors: Shino, M. Y., Weigt, S. S., Li, N., Derhovanessian, A., Sayah, D. M., Huynh, R. H., Saggar, R., Gregson, A. L., Ardehali, A., Ross, D. J., Lynch, J. P., Elashoff, R. M., Belperio, J. A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.05.2017
• Subjects: Acute Lung Injury - diagnosis; Acute Lung Injury - etiology; Bronchoalveolar Lavage Fluid - chemistry; chemokines/chemokine receptors; clinical research/practice; Female; Follow-Up Studies; Graft Rejection - diagnosis; Graft Rejection - etiology; Graft Survival; Health risk assessment; Humans; immunobiology; Ligands; lung (allograft) function/dysfunction; lung failure/injury; Lung Transplantation - adverse effects; lung transplantation/pulmonology; Male; Middle Aged; Pneumonia; Prognosis; Pulmonary Alveoli - pathology; rejection: acute; rejection: chronic; Retrospective Studies; translational research/science; Transplantation, Homologous; Transplants & implants; lung (allograft) function/dysfunction; rejection: acute; translational research/science; clinical research/practice; lung transplantation/pulmonology; chemokines/chemokine receptors; immunobiology; rejection: chronic; lung failure/injury

The impact of allograft injury time of onset on the risk of chronic lung allograft dysfunction (CLAD) remains unknown. We hypothesized that episodes of late‐onset (≥6 months) allograft injury would produce an augmented CXCR3/ligand immune response, leading to increased CLAD. In a retrospective singl...