Visceral obesity relates to deep white matter hyperintensities via inflammation

• Published in: Annals of neurology Vol. 85; no. 2; pp. 194 - 203
• Main Authors: Lampe, Leonie, Zhang, Rui, Beyer, Frauke, Huhn, Sebastian, Kharabian Masouleh, Shahrzad, Preusser, Sven, Bazin, Pierre‐Louis, Schroeter, Matthias L., Villringer, Arno, Witte, A. Veronica
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.02.2019; Wiley Subscription Services, Inc
• Subjects: Adult; Age factors; Aged; Aged, 80 and over; Blood pressure; Body mass; Body Mass Index; Body size; Brain; Cognitive ability; Cohort Studies; Confidence intervals; Correlation analysis; Cytokines; Dementia disorders; Diabetes mellitus; Error correction; Female; Hip; Humans; Hypertension; Inflammation; Inflammation - blood; Inflammation - diagnostic imaging; Inflammation Mediators - blood; Interleukin 6; Lesions; Longitudinal studies; Magnetic resonance imaging; Male; Mediation; Middle Aged; Neuroimaging; Obesity; Obesity, Abdominal - blood; Obesity, Abdominal - diagnostic imaging; Proteins; Regional analysis; Regression analysis; Risk analysis; Risk factors; Smoking; Statistical analysis; Substantia alba; Waist-Hip Ratio; White Matter - diagnostic imaging; Young Adult

Objective White matter hyperintensities (WMHs) are linked to vascular risk factors and increase the risk of cognitive decline, dementia, and stroke. We here aimed to determine whether obesity contributes to regional WMHs using a whole‐brain approach in a well‐characterized population‐based cohort. M...