Autophagy‐related genes in Helicobacter pylori infection

• Published in: Helicobacter (Cambridge, Mass.) Vol. 22; no. 3
• Main Authors: Tanaka, Shingo, Nagashima, Hiroyuki, Uotani, Takahiro, Graham, David Y., Yamaoka, Yoshio
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.06.2017
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; ATG16L1; ATG5; Autophagy; Bhutan; DNA microarrays; Epithelial cells; Female; Gastric mucosa; Gastric Mucosa - immunology; Gastric Mucosa - pathology; Gene expression; Gene Expression Profiling; Genes; Genetic Predisposition to Disease; Genotypes; Helicobacter Infections - immunology; Helicobacter Infections - pathology; Helicobacter pylori; Helicobacter pylori - immunology; Humans; In vitro methods and tests; Infections; Male; Maturation; Microarray Analysis; Middle Aged; Phagocytosis; Polymerase chain reaction; Polymorphism, Single Nucleotide; RNA-directed DNA polymerase; single nucleotide polymorphisms; Single-nucleotide polymorphism; Volunteers; Young Adult; autophagy; Helicobacter pylori; single nucleotide polymorphisms; ATG16L1; ATG5

Background In vitro studies have shown that Helicobacter pylori (H. pylori) infection induces autophagy in gastric epithelial cells. However, prolonged exposure to H. pylori reduces autophagy by preventing maturation of the autolysosome. The alterations of the autophagy‐related genes in H. pylori in...