Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1

• Published in: British journal of pharmacology Vol. 171; no. 2; pp. 523 - 535
• Main Authors: Arunachalam, Gnanapragasam, Samuel, Samson Mathews, Marei, Isra, Ding, Hong, Triggle, Chris R
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.01.2014; John Wiley & sons
• Subjects: Acetylation; Adenylate Kinase - metabolism; Animals; Apoptosis - drug effects; beta-Galactosidase - metabolism; Blotting, Western; Capillaries - cytology; Capillaries - drug effects; Cellular Senescence - drug effects; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; endothelial dysfunction; Endothelium, Vascular - drug effects; Fluorescent Antibody Technique; forkhead box O1 transcription factor; Forkhead Box Protein O1; Forkhead Transcription Factors - metabolism; FoxO‐1; Gene Silencing; hyperglycaemia; Hyperglycemia - physiopathology; Hypoglycemic Agents - pharmacology; metformin; Metformin - pharmacology; Mice; Mice, Inbred C57BL; microvascular endothelial cells; reactive oxygen species; Reactive Oxygen Species - metabolism; Research Papers; Signal Transduction - drug effects; Sirtuin 1 - genetics; Sirtuin 1 - physiology; sirtuin1; vascular senescence; FoxO-1; forkhead box O1 transcription factor; reactive oxygen species; sirtuin1; hyperglycaemia; metformin; vascular senescence; endothelial dysfunction; microvascular endothelial cells

Background and Purpose Endothelial dysfunction can be detected at an early stage in the development of diabetes‐related microvascular disease and is associated with accelerated endothelial senescence and ageing. Hyperglycaemia‐induced oxidative stress is a major contributing factor to the developmen...