Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers

• Published in: Clinical and translational science Vol. 14; no. 6; pp. 2487 - 2496
• Main Authors: Amore, Benny M., Cramer, Clay T., MacDougall, Diane E., Sasiela, William J., Emery, Maurice G.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.11.2021; John Wiley and Sons Inc; Wiley
• Subjects: Acids; Adenosine triphosphate; Adolescent; Adult; Antibiotics; Antigens; Arrhythmias, Cardiac - drug therapy; Blood pressure; Cardiovascular disease; Dicarboxylic Acids - pharmacology; Dose-Response Relationship, Drug; Double-Blind Method; Drug dosages; Electrocardiography; Enzyme Inhibitors - pharmacology; Fatty Acids - pharmacology; FDA approval; Female; Healthy Volunteers; Heart Rate - drug effects; Hepatitis; Humans; Hypercholesterolemia; Laboratory animals; Long QT Syndrome; Male; Middle Aged; Mortality; Moxifloxacin; Placebos; Potassium; Young Adult; United States > US

Bempedoic acid is an inhibitor of adenosine triphosphate–citrate lyase approved for use in adults with hypercholesterolemia. Nonclinical studies assessed binding to the human ether‐a‐go‐go–related gene (hERG) potassium channel in vitro and the effect of bempedoic acid on QT/QTc in cynomolgus monkeys...