Variant‐specific and reciprocal Hsp40 functions in Hsp104‐mediated prion elimination

• Published in: Molecular microbiology Vol. 109; no. 1; pp. 41 - 62
• Main Authors: Astor, Michael T., Kamiya, Erina, Sporn, Zachary A., Berger, Scott E., Hines, Justin K.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.07.2018; John Wiley and Sons Inc
• Subjects: Baking yeast; Chaperones; Cures; Curing; Hsp40 protein; Hsp70 protein; Molecular chains; Prion protein; Prions; Protein folding; Proteins; Saccharomyces cerevisiae; Well construction; Yeast

Summary The amyloid‐based prions of Saccharomyces cerevisiae are heritable aggregates of misfolded proteins, passed to daughter cells following fragmentation by molecular chaperones including the J‐protein Sis1, Hsp70 and Hsp104. Overexpression of Hsp104 efficiently cures cell populations of the pri...