Pharmacokinetics and pharmacodynamics of oral heparin solid dosage form in healthy human subjects

• Published in: Journal of clinical pharmacology Vol. 47; no. 12; p. 1508
• Main Authors: Mousa, Shaker A, Zhang, Fuming, Aljada, Ahmad, Chaturvedi, Seema, Takieddin, Majde, Zhang, Haifeng, Chi, Lianli, Castelli, M Cristina, Friedman, Kristen, Goldberg, Michael M, Linhardt, Robert J
• Format: Journal Article
• Language: English
• Published: England 01.12.2007
• Subjects: Administration, Oral; Adult; Caprylates - chemistry; Capsules; Chromatography, High Pressure Liquid; Cross-Over Studies; Gelatin - chemistry; Heparin, Low-Molecular-Weight - administration & dosage; Heparin, Low-Molecular-Weight - chemistry; Heparin, Low-Molecular-Weight - pharmacokinetics; Humans; Injections, Intravenous; Injections, Subcutaneous; Male; Middle Aged; Spectrometry, Mass, Electrospray Ionization

The present investigation determined the molecular structure and the pharmacokinetic and pharmacodynamic profiles of oral unfractionated heparin containing oral absorption enhancer sodium N-[8-(2-hydroxybenzoyl) amino]caprylate, salcaprozate sodium (SNAC) and assessed the safety and tolerability of...