Transcutaneous oxygen measurement in humans using a paramagnetic skin adhesive film
Purpose Transcutaneous oxygen tension (TcpO2) provides information about blood perfusion in the tissue immediately below the skin. These data are valuable in assessing wound healing problems, diagnosing peripheral vascular/arterial insufficiency, and predicting disease progression or the response to...
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| Published in | Magnetic resonance in medicine Vol. 81; no. 2; pp. 781 - 794 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wiley Subscription Services, Inc
01.02.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0740-3194 1522-2594 1522-2594 |
| DOI | 10.1002/mrm.27445 |
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| Abstract | Purpose
Transcutaneous oxygen tension (TcpO2) provides information about blood perfusion in the tissue immediately below the skin. These data are valuable in assessing wound healing problems, diagnosing peripheral vascular/arterial insufficiency, and predicting disease progression or the response to therapy. Currently, TcpO2 is primarily measured using electrochemical skin sensors, which consume oxygen and are prone to calibration errors. The goal of the present study was to develop a reliable method for TcpO2 measurement in human subjects.
Methods
We have developed a novel TcpO2 oximetry method based on electron paramagnetic resonance (EPR) principles with an oxygen‐sensing skin adhesive film, named the superficial perfusion oxygen tension (SPOT) chip. The SPOT chip is a 3‐mm diameter, 60‐μm thick circular film composed of a stable paramagnetic oxygen sensor. The chip is covered with an oxygen‐barrier material on one side and secured on the skin by a medical adhesive transfer tape to ensure that only the oxygen that diffuses through the skin surface is measured. The method quantifies TcpO2 through the linewidth of the EPR spectrum.
Results
Repeated measurements using a cohort of 10 healthy human subjects showed that the TcpO2 measurements were robust, reliable, and reproducible. The TcpO2 values ranged from 7.8 ± 0.8 to 22.0 ± 1.0 mmHg in the volar forearm skin (N = 29) and 8.1 ± 0.3 to 23.4 ± 1.3 mmHg in the foot (N = 86).
Conclusions
The results demonstrated that the SPOT chip can measure TcpO2 reliably and repeatedly under ambient conditions. The SPOT chip method could potentially be used to monitor TcpO2 in the clinic. |
|---|---|
| AbstractList | Purpose
Transcutaneous oxygen tension (TcpO2) provides information about blood perfusion in the tissue immediately below the skin. These data are valuable in assessing wound healing problems, diagnosing peripheral vascular/arterial insufficiency, and predicting disease progression or the response to therapy. Currently, TcpO2 is primarily measured using electrochemical skin sensors, which consume oxygen and are prone to calibration errors. The goal of the present study was to develop a reliable method for TcpO2 measurement in human subjects.
Methods
We have developed a novel TcpO2 oximetry method based on electron paramagnetic resonance (EPR) principles with an oxygen‐sensing skin adhesive film, named the superficial perfusion oxygen tension (SPOT) chip. The SPOT chip is a 3‐mm diameter, 60‐μm thick circular film composed of a stable paramagnetic oxygen sensor. The chip is covered with an oxygen‐barrier material on one side and secured on the skin by a medical adhesive transfer tape to ensure that only the oxygen that diffuses through the skin surface is measured. The method quantifies TcpO2 through the linewidth of the EPR spectrum.
Results
Repeated measurements using a cohort of 10 healthy human subjects showed that the TcpO2 measurements were robust, reliable, and reproducible. The TcpO2 values ranged from 7.8 ± 0.8 to 22.0 ± 1.0 mmHg in the volar forearm skin (N = 29) and 8.1 ± 0.3 to 23.4 ± 1.3 mmHg in the foot (N = 86).
Conclusions
The results demonstrated that the SPOT chip can measure TcpO2 reliably and repeatedly under ambient conditions. The SPOT chip method could potentially be used to monitor TcpO2 in the clinic. Transcutaneous oxygen tension (TcpO2 ) provides information about blood perfusion in the tissue immediately below the skin. These data are valuable in assessing wound healing problems, diagnosing peripheral vascular/arterial insufficiency, and predicting disease progression or the response to therapy. Currently, TcpO2 is primarily measured using electrochemical skin sensors, which consume oxygen and are prone to calibration errors. The goal of the present study was to develop a reliable method for TcpO2 measurement in human subjects.PURPOSETranscutaneous oxygen tension (TcpO2 ) provides information about blood perfusion in the tissue immediately below the skin. These data are valuable in assessing wound healing problems, diagnosing peripheral vascular/arterial insufficiency, and predicting disease progression or the response to therapy. Currently, TcpO2 is primarily measured using electrochemical skin sensors, which consume oxygen and are prone to calibration errors. The goal of the present study was to develop a reliable method for TcpO2 measurement in human subjects.We have developed a novel TcpO2 oximetry method based on electron paramagnetic resonance (EPR) principles with an oxygen-sensing skin adhesive film, named the superficial perfusion oxygen tension (SPOT) chip. The SPOT chip is a 3-mm diameter, 60-μm thick circular film composed of a stable paramagnetic oxygen sensor. The chip is covered with an oxygen-barrier material on one side and secured on the skin by a medical adhesive transfer tape to ensure that only the oxygen that diffuses through the skin surface is measured. The method quantifies TcpO2 through the linewidth of the EPR spectrum.METHODSWe have developed a novel TcpO2 oximetry method based on electron paramagnetic resonance (EPR) principles with an oxygen-sensing skin adhesive film, named the superficial perfusion oxygen tension (SPOT) chip. The SPOT chip is a 3-mm diameter, 60-μm thick circular film composed of a stable paramagnetic oxygen sensor. The chip is covered with an oxygen-barrier material on one side and secured on the skin by a medical adhesive transfer tape to ensure that only the oxygen that diffuses through the skin surface is measured. The method quantifies TcpO2 through the linewidth of the EPR spectrum.Repeated measurements using a cohort of 10 healthy human subjects showed that the TcpO2 measurements were robust, reliable, and reproducible. The TcpO2 values ranged from 7.8 ± 0.8 to 22.0 ± 1.0 mmHg in the volar forearm skin (N = 29) and 8.1 ± 0.3 to 23.4 ± 1.3 mmHg in the foot (N = 86).RESULTSRepeated measurements using a cohort of 10 healthy human subjects showed that the TcpO2 measurements were robust, reliable, and reproducible. The TcpO2 values ranged from 7.8 ± 0.8 to 22.0 ± 1.0 mmHg in the volar forearm skin (N = 29) and 8.1 ± 0.3 to 23.4 ± 1.3 mmHg in the foot (N = 86).The results demonstrated that the SPOT chip can measure TcpO2 reliably and repeatedly under ambient conditions. The SPOT chip method could potentially be used to monitor TcpO2 in the clinic.CONCLUSIONSThe results demonstrated that the SPOT chip can measure TcpO2 reliably and repeatedly under ambient conditions. The SPOT chip method could potentially be used to monitor TcpO2 in the clinic. PurposeTranscutaneous oxygen tension (TcpO2) provides information about blood perfusion in the tissue immediately below the skin. These data are valuable in assessing wound healing problems, diagnosing peripheral vascular/arterial insufficiency, and predicting disease progression or the response to therapy. Currently, TcpO2 is primarily measured using electrochemical skin sensors, which consume oxygen and are prone to calibration errors. The goal of the present study was to develop a reliable method for TcpO2 measurement in human subjects.MethodsWe have developed a novel TcpO2 oximetry method based on electron paramagnetic resonance (EPR) principles with an oxygen‐sensing skin adhesive film, named the superficial perfusion oxygen tension (SPOT) chip. The SPOT chip is a 3‐mm diameter, 60‐μm thick circular film composed of a stable paramagnetic oxygen sensor. The chip is covered with an oxygen‐barrier material on one side and secured on the skin by a medical adhesive transfer tape to ensure that only the oxygen that diffuses through the skin surface is measured. The method quantifies TcpO2 through the linewidth of the EPR spectrum.ResultsRepeated measurements using a cohort of 10 healthy human subjects showed that the TcpO2 measurements were robust, reliable, and reproducible. The TcpO2 values ranged from 7.8 ± 0.8 to 22.0 ± 1.0 mmHg in the volar forearm skin (N = 29) and 8.1 ± 0.3 to 23.4 ± 1.3 mmHg in the foot (N = 86).ConclusionsThe results demonstrated that the SPOT chip can measure TcpO2 reliably and repeatedly under ambient conditions. The SPOT chip method could potentially be used to monitor TcpO2 in the clinic. Transcutaneous oxygen tension (TcpO ) provides information about blood perfusion in the tissue immediately below the skin. These data are valuable in assessing wound healing problems, diagnosing peripheral vascular/arterial insufficiency, and predicting disease progression or the response to therapy. Currently, TcpO is primarily measured using electrochemical skin sensors, which consume oxygen and are prone to calibration errors. The goal of the present study was to develop a reliable method for TcpO measurement in human subjects. We have developed a novel TcpO oximetry method based on electron paramagnetic resonance (EPR) principles with an oxygen-sensing skin adhesive film, named the superficial perfusion oxygen tension (SPOT) chip. The SPOT chip is a 3-mm diameter, 60-μm thick circular film composed of a stable paramagnetic oxygen sensor. The chip is covered with an oxygen-barrier material on one side and secured on the skin by a medical adhesive transfer tape to ensure that only the oxygen that diffuses through the skin surface is measured. The method quantifies TcpO through the linewidth of the EPR spectrum. Repeated measurements using a cohort of 10 healthy human subjects showed that the TcpO measurements were robust, reliable, and reproducible. The TcpO values ranged from 7.8 ± 0.8 to 22.0 ± 1.0 mmHg in the volar forearm skin (N = 29) and 8.1 ± 0.3 to 23.4 ± 1.3 mmHg in the foot (N = 86). The results demonstrated that the SPOT chip can measure TcpO reliably and repeatedly under ambient conditions. The SPOT chip method could potentially be used to monitor TcpO in the clinic. |
| Author | Drews, Thomas M. Kmiec, Maciej M. Buckey, Jay C. Blank, Aharon Lakshmi Kuppusamy, M. Petryakov, Sergey V. Schaner, Philip E. Prabhat, Anjali M. Hou, Huagang Demidenko, Eugene Kuppusamy, Periannan |
| AuthorAffiliation | c Department of Biomedical Data Sciences, Geisel School of Medicine, Dartmouth College, 1 Medical Center Drive, Lebanon, NH 03756, USA a Department of Radiology, Geisel School of Medicine, Dartmouth College, 1 Medical Center Drive, Lebanon, NH 03756, USA d Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA b Department of Medicine, Geisel School of Medicine, Dartmouth College, 1 Medical Center Drive, Lebanon, NH 03756, USA e Schulich Faculty of Chemistry Technion - Israel Institute of Technology, Haifa 32000, Israel |
| AuthorAffiliation_xml | – name: d Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA – name: e Schulich Faculty of Chemistry Technion - Israel Institute of Technology, Haifa 32000, Israel – name: c Department of Biomedical Data Sciences, Geisel School of Medicine, Dartmouth College, 1 Medical Center Drive, Lebanon, NH 03756, USA – name: a Department of Radiology, Geisel School of Medicine, Dartmouth College, 1 Medical Center Drive, Lebanon, NH 03756, USA – name: b Department of Medicine, Geisel School of Medicine, Dartmouth College, 1 Medical Center Drive, Lebanon, NH 03756, USA |
| Author_xml | – sequence: 1 givenname: Maciej M. surname: Kmiec fullname: Kmiec, Maciej M. organization: Dartmouth College – sequence: 2 givenname: Huagang surname: Hou fullname: Hou, Huagang organization: Dartmouth College – sequence: 3 givenname: M. surname: Lakshmi Kuppusamy fullname: Lakshmi Kuppusamy, M. organization: Dartmouth College – sequence: 4 givenname: Thomas M. surname: Drews fullname: Drews, Thomas M. organization: University of Massachusetts – sequence: 5 givenname: Anjali M. surname: Prabhat fullname: Prabhat, Anjali M. organization: Dartmouth College – sequence: 6 givenname: Sergey V. surname: Petryakov fullname: Petryakov, Sergey V. organization: Dartmouth College – sequence: 7 givenname: Eugene surname: Demidenko fullname: Demidenko, Eugene organization: Geisel School of Medicine, Dartmouth College – sequence: 8 givenname: Philip E. surname: Schaner fullname: Schaner, Philip E. organization: Geisel School of Medicine, Dartmouth College – sequence: 9 givenname: Jay C. surname: Buckey fullname: Buckey, Jay C. organization: Geisel School of Medicine, Dartmouth College – sequence: 10 givenname: Aharon surname: Blank fullname: Blank, Aharon organization: Israel Institute of Technology – sequence: 11 givenname: Periannan surname: Kuppusamy fullname: Kuppusamy, Periannan email: kuppu@dartmouth.edu organization: University of Massachusetts |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30277275$$D View this record in MEDLINE/PubMed |
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| Keywords | EPR Transcutaneous SPOT chip human subjects oximetry TcOM oxygen |
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Transcutaneous oxygen tension (TcpO2) provides information about blood perfusion in the tissue immediately below the skin. These data are valuable in... Transcutaneous oxygen tension (TcpO ) provides information about blood perfusion in the tissue immediately below the skin. These data are valuable in assessing... PurposeTranscutaneous oxygen tension (TcpO2) provides information about blood perfusion in the tissue immediately below the skin. These data are valuable in... Transcutaneous oxygen tension (TcpO2 ) provides information about blood perfusion in the tissue immediately below the skin. These data are valuable in... |
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| SubjectTerms | Adhesion tests Adhesives Adolescent Adult Arterial Occlusive Diseases - physiopathology Calibration Chemical sensors Cohort Studies Electron paramagnetic resonance Electron Spin Resonance Spectroscopy EPR Female Foot Forearm Healthy Volunteers Human subjects Humans Male Middle Aged Oximetry oxygen Oxygen - analysis Oxygen - blood Oxygen probes Oxygen tension Perfusion Peripheral Vascular Diseases - physiopathology Reproducibility of Results Skin Skin - blood supply Skin Physiological Phenomena SPOT chip TcOM Temperature Transcutaneous Wound Healing Young Adult |
| Title | Transcutaneous oxygen measurement in humans using a paramagnetic skin adhesive film |
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