Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis
Objective Development of proteinuria in lupus nephritis (LN) is associated with podocyte dysfunction. The NLRP3 inflammasome has been implicated in the pathogenesis of LN. The purpose of this study was to investigate whether NLRP3 inflammasome activation is involved in the development of podocyte in...
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| Published in | Arthritis & rheumatology (Hoboken, N.J.) Vol. 69; no. 8; pp. 1636 - 1646 |
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| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wiley Subscription Services, Inc
01.08.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Objective
Development of proteinuria in lupus nephritis (LN) is associated with podocyte dysfunction. The NLRP3 inflammasome has been implicated in the pathogenesis of LN. The purpose of this study was to investigate whether NLRP3 inflammasome activation is involved in the development of podocyte injury in LN.
Methods
A fluorescence‐labeled caspase 1 inhibitor probe was used to detect the activation of NLRP3 inflammasomes in podocytes derived from lupus‐prone NZM2328 mice and from renal biopsy tissues obtained from patients with LN. MCC950, a selective inhibitor of NLRP3, was used to treat NZM2328 mice. Proteinuria, podocyte ultrastructure, and renal pathology were evaluated. In vitro, sera from diseased NZM2328 mice were used to stimulate a podocyte cell line, and the cells were analyzed by flow cytometry.
Results
NLRP3 inflammasomes were activated in podocytes from lupus‐prone mice and from patients with LN. Inhibition of NLRP3 with MCC950 ameliorated proteinuria, renal histologic lesions, and podocyte foot process effacement in lupus‐prone mice. In vitro, sera from diseased NZM2328 mice activated NLRP3 inflammasomes in the podocyte cell line through the production of reactive oxygen species.
Conclusion
NLRP3 inflammasomes were activated in podocytes from lupus‐prone mice and from LN patients. Activation of NLRP3 is involved in the pathogenesis of podocyte injuries and the development of proteinuria in LN. |
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| AbstractList | Objective Development of proteinuria in lupus nephritis (LN) is associated with podocyte dysfunction. The NLRP3 inflammasome has been implicated in the pathogenesis of LN. The purpose of this study was to investigate whether NLRP3 inflammasome activation is involved in the development of podocyte injury in LN. Methods A fluorescence-labeled caspase 1 inhibitor probe was used to detect the activation of NLRP3 inflammasomes in podocytes derived from lupus-prone NZM2328 mice and from renal biopsy tissues obtained from patients with LN. MCC950, a selective inhibitor of NLRP3, was used to treat NZM2328 mice. Proteinuria, podocyte ultrastructure, and renal pathology were evaluated. In vitro, sera from diseased NZM2328 mice were used to stimulate a podocyte cell line, and the cells were analyzed by flow cytometry. Results NLRP3 inflammasomes were activated in podocytes from lupus-prone mice and from patients with LN. Inhibition of NLRP3 with MCC950 ameliorated proteinuria, renal histologic lesions, and podocyte foot process effacement in lupus-prone mice. In vitro, sera from diseased NZM2328 mice activated NLRP3 inflammasomes in the podocyte cell line through the production of reactive oxygen species. Conclusion NLRP3 inflammasomes were activated in podocytes from lupus-prone mice and from LN patients. Activation of NLRP3 is involved in the pathogenesis of podocyte injuries and the development of proteinuria in LN. Development of proteinuria in lupus nephritis (LN) is associated with podocyte dysfunction. The NLRP3 inflammasome has been implicated in the pathogenesis of LN. The purpose of this study was to investigate whether NLRP3 inflammasome activation is involved in the development of podocyte injury in LN.OBJECTIVEDevelopment of proteinuria in lupus nephritis (LN) is associated with podocyte dysfunction. The NLRP3 inflammasome has been implicated in the pathogenesis of LN. The purpose of this study was to investigate whether NLRP3 inflammasome activation is involved in the development of podocyte injury in LN.A fluorescence-labeled caspase 1 inhibitor probe was used to detect the activation of NLRP3 inflammasomes in podocytes derived from lupus-prone NZM2328 mice and from renal biopsy tissues obtained from patients with LN. MCC950, a selective inhibitor of NLRP3, was used to treat NZM2328 mice. Proteinuria, podocyte ultrastructure, and renal pathology were evaluated. In vitro, sera from diseased NZM2328 mice were used to stimulate a podocyte cell line, and the cells were analyzed by flow cytometry.METHODSA fluorescence-labeled caspase 1 inhibitor probe was used to detect the activation of NLRP3 inflammasomes in podocytes derived from lupus-prone NZM2328 mice and from renal biopsy tissues obtained from patients with LN. MCC950, a selective inhibitor of NLRP3, was used to treat NZM2328 mice. Proteinuria, podocyte ultrastructure, and renal pathology were evaluated. In vitro, sera from diseased NZM2328 mice were used to stimulate a podocyte cell line, and the cells were analyzed by flow cytometry.NLRP3 inflammasomes were activated in podocytes from lupus-prone mice and from patients with LN. Inhibition of NLRP3 with MCC950 ameliorated proteinuria, renal histologic lesions, and podocyte foot process effacement in lupus-prone mice. In vitro, sera from diseased NZM2328 mice activated NLRP3 inflammasomes in the podocyte cell line through the production of reactive oxygen species.RESULTSNLRP3 inflammasomes were activated in podocytes from lupus-prone mice and from patients with LN. Inhibition of NLRP3 with MCC950 ameliorated proteinuria, renal histologic lesions, and podocyte foot process effacement in lupus-prone mice. In vitro, sera from diseased NZM2328 mice activated NLRP3 inflammasomes in the podocyte cell line through the production of reactive oxygen species.NLRP3 inflammasomes were activated in podocytes from lupus-prone mice and from LN patients. Activation of NLRP3 is involved in the pathogenesis of podocyte injuries and the development of proteinuria in LN.CONCLUSIONNLRP3 inflammasomes were activated in podocytes from lupus-prone mice and from LN patients. Activation of NLRP3 is involved in the pathogenesis of podocyte injuries and the development of proteinuria in LN. Objective Development of proteinuria in lupus nephritis (LN) is associated with podocyte dysfunction. The NLRP3 inflammasome has been implicated in the pathogenesis of LN. The purpose of this study was to investigate whether NLRP3 inflammasome activation is involved in the development of podocyte injury in LN. Methods A fluorescence‐labeled caspase 1 inhibitor probe was used to detect the activation of NLRP3 inflammasomes in podocytes derived from lupus‐prone NZM2328 mice and from renal biopsy tissues obtained from patients with LN. MCC950, a selective inhibitor of NLRP3, was used to treat NZM2328 mice. Proteinuria, podocyte ultrastructure, and renal pathology were evaluated. In vitro, sera from diseased NZM2328 mice were used to stimulate a podocyte cell line, and the cells were analyzed by flow cytometry. Results NLRP3 inflammasomes were activated in podocytes from lupus‐prone mice and from patients with LN. Inhibition of NLRP3 with MCC950 ameliorated proteinuria, renal histologic lesions, and podocyte foot process effacement in lupus‐prone mice. In vitro, sera from diseased NZM2328 mice activated NLRP3 inflammasomes in the podocyte cell line through the production of reactive oxygen species. Conclusion NLRP3 inflammasomes were activated in podocytes from lupus‐prone mice and from LN patients. Activation of NLRP3 is involved in the pathogenesis of podocyte injuries and the development of proteinuria in LN. Development of proteinuria in lupus nephritis (LN) is associated with podocyte dysfunction. The NLRP3 inflammasome has been implicated in the pathogenesis of LN. The purpose of this study was to investigate whether NLRP3 inflammasome activation is involved in the development of podocyte injury in LN. A fluorescence-labeled caspase 1 inhibitor probe was used to detect the activation of NLRP3 inflammasomes in podocytes derived from lupus-prone NZM2328 mice and from renal biopsy tissues obtained from patients with LN. MCC950, a selective inhibitor of NLRP3, was used to treat NZM2328 mice. Proteinuria, podocyte ultrastructure, and renal pathology were evaluated. In vitro, sera from diseased NZM2328 mice were used to stimulate a podocyte cell line, and the cells were analyzed by flow cytometry. NLRP3 inflammasomes were activated in podocytes from lupus-prone mice and from patients with LN. Inhibition of NLRP3 with MCC950 ameliorated proteinuria, renal histologic lesions, and podocyte foot process effacement in lupus-prone mice. In vitro, sera from diseased NZM2328 mice activated NLRP3 inflammasomes in the podocyte cell line through the production of reactive oxygen species. NLRP3 inflammasomes were activated in podocytes from lupus-prone mice and from LN patients. Activation of NLRP3 is involved in the pathogenesis of podocyte injuries and the development of proteinuria in LN. |
| Author | Huang, Yuefang Gaskin, Felicia Hu, Haoqiang Fu, Shu Man Guo, Chaohuan Zhao, Jijun Xu, Bihua Yang, Niansheng Zhou, Mianjing Sung, Sun‐sang J. Fu, Rong Chen, Jingxian Wang, Hongyang Jin, Ou Wang, Shuang |
| AuthorAffiliation | 1 Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China 7 Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908-0133, USA 5 Division of Rheumatology and Center of Inflammation, Immunology and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908-0133, USA 6 Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908-0133, USA 2 Department of Pediatrics, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China 3 Department of Rheumatology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China 4 Department of Nephrology, Dongguan People’s Hospital, Dongguan, PR China |
| AuthorAffiliation_xml | – name: 6 Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908-0133, USA – name: 2 Department of Pediatrics, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China – name: 1 Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China – name: 4 Department of Nephrology, Dongguan People’s Hospital, Dongguan, PR China – name: 3 Department of Rheumatology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China – name: 7 Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908-0133, USA – name: 5 Division of Rheumatology and Center of Inflammation, Immunology and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908-0133, USA |
| Author_xml | – sequence: 1 givenname: Rong surname: Fu fullname: Fu, Rong organization: First Affiliated Hospital, Sun Yat‐sen University – sequence: 2 givenname: Chaohuan surname: Guo fullname: Guo, Chaohuan organization: First Affiliated Hospital, Sun Yat‐sen University – sequence: 3 givenname: Shuang surname: Wang fullname: Wang, Shuang organization: First Affiliated Hospital, Sun Yat‐sen University – sequence: 4 givenname: Yuefang surname: Huang fullname: Huang, Yuefang organization: First Affiliated Hospital, Sun Yat‐sen University – sequence: 5 givenname: Ou surname: Jin fullname: Jin, Ou organization: Third Affiliated Hospital, Sun Yat‐sen University – sequence: 6 givenname: Haoqiang surname: Hu fullname: Hu, Haoqiang organization: Dongguan People's Hospital – sequence: 7 givenname: Jingxian surname: Chen fullname: Chen, Jingxian organization: First Affiliated Hospital, Sun Yat‐sen University – sequence: 8 givenname: Bihua surname: Xu fullname: Xu, Bihua organization: First Affiliated Hospital, Sun Yat‐sen University – sequence: 9 givenname: Mianjing surname: Zhou fullname: Zhou, Mianjing organization: First Affiliated Hospital, Sun Yat‐sen University – sequence: 10 givenname: Jijun surname: Zhao fullname: Zhao, Jijun organization: First Affiliated Hospital, Sun Yat‐sen University – sequence: 11 givenname: Sun‐sang J. surname: Sung fullname: Sung, Sun‐sang J. organization: University of Virginia – sequence: 12 givenname: Hongyang surname: Wang fullname: Wang, Hongyang organization: University of Virginia – sequence: 13 givenname: Felicia surname: Gaskin fullname: Gaskin, Felicia organization: University of Virginia – sequence: 14 givenname: Niansheng surname: Yang fullname: Yang, Niansheng email: zsuyns@163.com organization: First Affiliated Hospital, Sun Yat‐sen University – sequence: 15 givenname: Shu Man surname: Fu fullname: Fu, Shu Man organization: University of Virginia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28544564$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1097/MNH.0000000000000124 10.1006/clim.2001.5079 10.1152/ajprenal.00404.2002 10.1073/pnas.98.2.646 10.1093/rheumatology/ket491 10.1097/00000441-200008000-00009 10.1038/ki.2014.271 10.1159/000438843 10.1038/nrneph.2012.141 10.1084/jem.20130731 10.1111/nep.12785 10.1159/000368511 10.1177/0961203313517152 10.1038/nm.3806 10.1152/ajprenal.00203.2014 10.1002/acr.20116 10.1016/S0002-9440(10)64239-3 10.1038/srep24667 10.1172/JCI116956 10.1016/j.jaut.2015.05.001 10.1038/srep10901 10.1002/art.38993 10.1016/j.febslet.2006.12.051 10.1093/jb/mvw098 10.1016/j.cell.2014.04.007 10.1038/ki.1995.185 10.1016/0162-3109(95)00014-K 10.1016/j.coi.2014.10.004 10.1084/jem.20031519 10.1038/ki.1993.70 10.4049/jimmunol.1601565 10.1038/nri3452 10.1128/MCB.9.4.1672 10.1038/ki.1997.346 10.1002/art.39499 10.1093/ndt/12.6.1109 10.1002/art.38174 |
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| Copyright | 2017, American College of Rheumatology 2017, American College of Rheumatology. |
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| Notes | Supported by the National Natural Science Foundation of China (grants 81471598 and 81671593), the Guangdong Natural Science Foundation (grant 2014A030313096), and the Guangzhou Science and Technology Planning Program (grant 201605122113460). Dr. S. M. Fu's work was supported in part by the NIH (grant R01‐AR‐047988) and the Alliance for Lupus Research (grant TIL332635). Drs. R. Fu, Guo, and S. Wang contributed equally to this work. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work. |
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| References | 2001; 100 2015; 1 1995; 30 2015; 5 2013; 65 1993; 43 1989; 9 2007; 581 2015; 308 2017; 198 2014; 23 1996; 76 2010; 62 2014; 157 2015; 24 2015; 67 2004; 199 2016; 6 2002; 161 2015; 40 2013; 13 2015; 61 1997; 52 1995; 47 2015; 87 2015; 21 1997; 12 2013; 210 2017 2016 2000; 320 1994; 93 2016; 68 2012; 8 2003; 285 2014; 53 2001; 98 2014; 31 Sun H (e_1_2_6_34_1) 1996; 76 e_1_2_6_32_1 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_30_1 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_36_1 e_1_2_6_14_1 e_1_2_6_35_1 e_1_2_6_11_1 e_1_2_6_12_1 e_1_2_6_33_1 e_1_2_6_17_1 e_1_2_6_18_1 e_1_2_6_39_1 e_1_2_6_15_1 e_1_2_6_38_1 e_1_2_6_16_1 e_1_2_6_37_1 e_1_2_6_21_1 e_1_2_6_20_1 e_1_2_6_9_1 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_7_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_22_1 e_1_2_6_29_1 e_1_2_6_28_1 e_1_2_6_27_1 e_1_2_6_26_1 28544537 - Arthritis Rheumatol. 2017 Aug;69(8):1517-1520 |
| References_xml | – volume: 8 start-page: 505 year: 2012 end-page: 14 article-title: B‐cell depletion in the treatment of lupus nephritis publication-title: Nat Rev Nephrol – volume: 53 start-page: 1235 year: 2014 end-page: 44 article-title: Podocyte involvement in lupus nephritis based on the 2003 ISN/RPS system: a large cohort study from a single centre publication-title: Rheumatology (Oxford) – volume: 210 start-page: 2387 year: 2013 end-page: 401 article-title: Cgnz1 allele confers kidney resistance to damage preventing progression of immune complex‐mediated acute lupus glomerulonephritis publication-title: J Exp Med – volume: 76 start-page: 600 year: 1996 end-page: 2 article-title: Study of immunoregulation by interleukin‐1 receptor antagonist in NZB/W F1 mice publication-title: Zhonghua Yi Xue Za Zhi – volume: 23 start-page: 255 year: 2014 end-page: 62 article-title: Podocyte injury in pure membranous and proliferative lupus nephritis: distinct underlying mechanisms of proteinuria? publication-title: Lupus – volume: 6 start-page: 24667 year: 2016 article-title: NLRP3 localizes to the tubular epithelium in human kidney and correlates with outcome in IgA nephropathy publication-title: Sci Rep – volume: 47 start-page: 1303 year: 1995 end-page: 9 article-title: Interleukin‐1 receptor antagonist halts the progression of established crescentic glomerulonephritis in the rat publication-title: Kidney Int – volume: 199 start-page: 255 year: 2004 end-page: 64 article-title: Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis publication-title: J Exp Med – volume: 68 start-page: 944 year: 2016 end-page: 52 article-title: Lupus nephritis IgG induction of calcium/calmodulin‐dependent protein kinase IV expression in podocytes and alteration of their function publication-title: Arthritis Rheumatol – year: 2017 article-title: Mitochondrial function is required for extracellular ATP‐induced NLRP3 inflammasome activation publication-title: J Biochem – volume: 98 start-page: 646 year: 2001 end-page: 51 article-title: Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells publication-title: Proc Natl Acad Sci U S A – volume: 1 start-page: 187 year: 2015 end-page: 93 article-title: Inflammasomes in the pathophysiology of kidney diseases publication-title: Kidney Dis (Basel) – volume: 320 start-page: 112 year: 2000 end-page: 6 article-title: Urinary podocytes for the assessment of disease activity in lupus nephritis publication-title: Am J Med Sci – volume: 581 start-page: 421 year: 2007 end-page: 6 article-title: Transcriptional suppression of nephrin in podocyte by macrophage: roles of inflammatory cytokines and involvement of PI3K/Akt pathway publication-title: FEBS Lett – volume: 5 start-page: 10901 year: 2015 article-title: Role of NLRP3 inflammasomes for rhabdomyolysis‐induced acute kidney injury publication-title: Sci Rep – volume: 87 start-page: 74 year: 2015 end-page: 84 article-title: Nlrp3‐inflammasome activation in non‐myeloid‐derived cells aggravates diabetic nephropathy publication-title: Kidney Int – volume: 21 start-page: 248 year: 2015 end-page: 55 article-title: A small‐molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases publication-title: Nat Med – volume: 52 start-page: 393 year: 1997 end-page: 403 article-title: Podocytes are the major source of IL‐1α and IL‐1β in human glomerulonephritides publication-title: Kidney Int – volume: 285 start-page: F40 year: 2003 end-page: 48 article-title: Urinary excretion of viable podocytes in health and renal disease publication-title: Am J Physiol Renal Physiol – volume: 13 start-page: 397 year: 2013 end-page: 411 article-title: Activation and regulation of the inflammasomes [review] publication-title: Nat Rev Immunol – volume: 67 start-page: 1036 year: 2015 end-page: 44 article-title: Lupus nephritis: glycogen synthase kinase 3β promotion of renal damage through activation of the NLRP3 inflammasome in lupus‐prone mice publication-title: Arthritis Rheumatol – volume: 198 start-page: 2589 year: 2017 end-page: 601 article-title: Dependence of glomerulonephritis induction on novel intraglomerular alternatively activated bone marrow‐derived macrophages and Mac‐1 and PD‐L1 in lupus‐prone NZM2328 mice publication-title: J Immunol – volume: 30 start-page: 131 year: 1995 end-page: 7 article-title: Established murine lupus nephritis does not respond to exogenous interleukin‐1 receptor antagonist; a role for the endogenous molecule? publication-title: Immunopharmacology – volume: 12 start-page: 1109 year: 1997 end-page: 15 article-title: Intrinsic renal cells are the major source of interleukin‐1β synthesis in normal and diseased rat kidney publication-title: Nephrol Dial Transplant – volume: 24 start-page: 239 year: 2015 end-page: 44 article-title: Podocyte injury and repair mechanisms publication-title: Curr Opin Nephrol Hypertens – volume: 40 start-page: 344 year: 2015 end-page: 54 article-title: The expression and significance of NLRP3 inflammasome in patients with primary glomerular diseases publication-title: Kidney Blood Press Res – volume: 93 start-page: 273 year: 1994 end-page: 79 article-title: Interleukin‐1 receptor antagonist ameliorates experimental anti‐glomerular basement membrane antibody‐associated glomerulonephritis publication-title: J Clin Invest – volume: 9 start-page: 1672 year: 1989 end-page: 81 article-title: Cell lines established by a temperature‐sensitive simian virus 40 large‐T‐antigen gene are growth restricted at the nonpermissive temperature publication-title: Mol Cell Biol – start-page: 736 year: 2016 end-page: 44 article-title: The NLRP3 inflammasome in kidney disease and autoimmunity publication-title: Nephrology (Carlton) – volume: 31 start-page: 87 year: 2014 end-page: 96 article-title: Genetics of systemic lupus erythematosus: immune responses and end organ resistance to damage publication-title: Curr Opin Immunol – volume: 308 start-page: F857 year: 2015 end-page: 66 article-title: Mitochondrial dysfunction confers albumin‐induced NLRP3 inflammasome activation and renal tubular injury publication-title: Am J Physiol Renal Physiol – volume: 43 start-page: 479 year: 1993 end-page: 85 article-title: Suppression of experimental crescentic glomerulonephritis by the interleukin‐1 receptor antagonist publication-title: Kidney Int – volume: 100 start-page: 372 year: 2001 end-page: 83 article-title: NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci publication-title: Clin Immunol – volume: 62 start-page: 873 year: 2010 end-page: 80 article-title: Long‐term mortality and renal outcome in a cohort of 100 patients with lupus nephritis publication-title: Arthritis Care Res (Hoboken) – volume: 65 start-page: 3176 year: 2013 end-page: 85 article-title: P2X blockade attenuates murine lupus nephritis by inhibiting activation of the NLRP3/ASC/caspase 1 pathway publication-title: Arthritis Rheum – volume: 157 start-page: 1013 year: 2014 end-page: 22 article-title: Mechanisms and functions of inflammasomes [review] publication-title: Cell – volume: 61 start-page: 1 year: 2015 end-page: 8 article-title: Inflammasomes and human autoimmunity: a comprehensive review [review] publication-title: J Autoimmun – volume: 161 start-page: 799 year: 2002 end-page: 805 article-title: A new method for large scale isolation of kidney glomeruli from mice publication-title: Am J Pathol – ident: e_1_2_6_5_1 doi: 10.1097/MNH.0000000000000124 – ident: e_1_2_6_11_1 doi: 10.1006/clim.2001.5079 – ident: e_1_2_6_38_1 doi: 10.1152/ajprenal.00404.2002 – ident: e_1_2_6_15_1 doi: 10.1073/pnas.98.2.646 – ident: e_1_2_6_4_1 doi: 10.1093/rheumatology/ket491 – ident: e_1_2_6_39_1 doi: 10.1097/00000441-200008000-00009 – ident: e_1_2_6_6_1 doi: 10.1038/ki.2014.271 – ident: e_1_2_6_23_1 doi: 10.1159/000438843 – ident: e_1_2_6_2_1 doi: 10.1038/nrneph.2012.141 – ident: e_1_2_6_20_1 doi: 10.1084/jem.20130731 – ident: e_1_2_6_22_1 doi: 10.1111/nep.12785 – ident: e_1_2_6_21_1 doi: 10.1159/000368511 – ident: e_1_2_6_17_1 doi: 10.1177/0961203313517152 – ident: e_1_2_6_16_1 doi: 10.1038/nm.3806 – volume: 76 start-page: 600 year: 1996 ident: e_1_2_6_34_1 article-title: Study of immunoregulation by interleukin‐1 receptor antagonist in NZB/W F1 mice publication-title: Zhonghua Yi Xue Za Zhi – ident: e_1_2_6_26_1 doi: 10.1152/ajprenal.00203.2014 – ident: e_1_2_6_3_1 doi: 10.1002/acr.20116 – ident: e_1_2_6_12_1 doi: 10.1016/S0002-9440(10)64239-3 – ident: e_1_2_6_24_1 doi: 10.1038/srep24667 – ident: e_1_2_6_31_1 doi: 10.1172/JCI116956 – ident: e_1_2_6_8_1 doi: 10.1016/j.jaut.2015.05.001 – ident: e_1_2_6_25_1 doi: 10.1038/srep10901 – ident: e_1_2_6_10_1 doi: 10.1002/art.38993 – ident: e_1_2_6_27_1 doi: 10.1016/j.febslet.2006.12.051 – ident: e_1_2_6_36_1 doi: 10.1093/jb/mvw098 – ident: e_1_2_6_7_1 doi: 10.1016/j.cell.2014.04.007 – ident: e_1_2_6_32_1 doi: 10.1038/ki.1995.185 – ident: e_1_2_6_33_1 doi: 10.1016/0162-3109(95)00014-K – ident: e_1_2_6_19_1 doi: 10.1016/j.coi.2014.10.004 – ident: e_1_2_6_18_1 doi: 10.1084/jem.20031519 – ident: e_1_2_6_30_1 doi: 10.1038/ki.1993.70 – ident: e_1_2_6_13_1 doi: 10.4049/jimmunol.1601565 – ident: e_1_2_6_35_1 doi: 10.1038/nri3452 – ident: e_1_2_6_14_1 doi: 10.1128/MCB.9.4.1672 – ident: e_1_2_6_28_1 doi: 10.1038/ki.1997.346 – ident: e_1_2_6_37_1 doi: 10.1002/art.39499 – ident: e_1_2_6_29_1 doi: 10.1093/ndt/12.6.1109 – ident: e_1_2_6_9_1 doi: 10.1002/art.38174 – reference: 28544537 - Arthritis Rheumatol. 2017 Aug;69(8):1517-1520 |
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Development of proteinuria in lupus nephritis (LN) is associated with podocyte dysfunction. The NLRP3 inflammasome has been implicated in the... Development of proteinuria in lupus nephritis (LN) is associated with podocyte dysfunction. The NLRP3 inflammasome has been implicated in the pathogenesis of... Objective Development of proteinuria in lupus nephritis (LN) is associated with podocyte dysfunction. The NLRP3 inflammasome has been implicated in the... |
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| SubjectTerms | Activation Activation analysis Animals Autoimmune diseases Biopsy Blotting, Western Caspase Caspase 1 - drug effects Caspase 1 - immunology Caspase 1 - metabolism Caspase-1 Cell Line Cytometry Feet Flow Cytometry Fluorescence Heterocyclic Compounds, 4 or More Rings - pharmacology Humans In vitro methods and tests Inflammasomes Inhibitors Interleukin-1beta - drug effects Interleukin-1beta - immunology Interleukin-1beta - metabolism Kidney - drug effects Kidney - immunology Kidney - metabolism Kidney - ultrastructure Kidney Glomerulus - drug effects Kidney Glomerulus - immunology Kidney Glomerulus - metabolism Kidney Glomerulus - ultrastructure Kidneys Lesions Lupus Lupus nephritis Lupus Nephritis - immunology Lupus Nephritis - metabolism Lupus Nephritis - pathology Mice Microscopy, Confocal Microscopy, Electron, Transmission Nephritis NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors NLR Family, Pyrin Domain-Containing 3 Protein - immunology Pathogenesis Patients Podocytes - drug effects Podocytes - immunology Podocytes - ultrastructure Proteinuria Proteinuria - immunology Proteinuria - metabolism Proteinuria - pathology Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Sulfones - pharmacology Tissues Ultrastructure |
| Title | Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis |
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