Transcriptional Dynamics of Hepatic Sinusoid‐Associated Cells After Liver Injury

• Published in: Hepatology (Baltimore, Md.) Vol. 72; no. 6; pp. 2119 - 2133
• Main Authors: Terkelsen, Mike K., Bendixen, Sofie M., Hansen, Daniel, Scott, Emma A.H., Moeller, Andreas F., Nielsen, Ronni, Mandrup, Susanne, Schlosser, Anders, Andersen, Thomas L., Sorensen, Grith L., Krag, Aleksander, Natarajan, Kedar N., Detlefsen, Sönke, Dimke, Henrik, Ravnskjaer, Kim
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2020; John Wiley and Sons Inc
• Subjects: Animals; Biopsy; Capillaries - cytology; Capillaries - pathology; Carbon Tetrachloride - administration & dosage; Carbon Tetrachloride - toxicity; Cell activation; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - pathology; Disease Models, Animal; Endothelial cells; Endothelial Cells - pathology; Endothelium, Vascular - cytology; Endothelium, Vascular - pathology; Female; Fibrosis; Gene Regulatory Networks; Genes; Hepatic Veins - cytology; Hepatic Veins - pathology; Hepatocytes; Hepatology; Humans; Kupffer cells; Liver; Liver - blood supply; Liver - pathology; Liver Cirrhosis - genetics; Liver Cirrhosis - pathology; Liver diseases; Membrane Proteins - genetics; Mice; Mice, Transgenic; Non-alcoholic Fatty Liver Disease - pathology; Oligonucleotide Array Sequence Analysis; Original; Plasma membranes; RNA-Seq; Single-Cell Analysis; Stellate cells; Transcription

Background and Aims Hepatic sinusoidal cells are known actors in the fibrogenic response to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and Kupffer cells are responsible for sinusoidal capillarization and perisinusoidal matrix deposition, impairing vascular e...