FKBP5 polymorphisms influence pre‐learning stress‐induced alterations of learning and memory

• Published in: The European journal of neuroscience Vol. 45; no. 5; pp. 648 - 659
• Main Authors: Zoladz, Phillip R., Dailey, Alison M., Nagle, Hannah E., Fiely, Miranda K., Mosley, Brianne E., Brown, Callie M., Duffy, Tessa J., Scharf, Amanda R., Earley, McKenna B., Rorabaugh, Boyd R., Rossell, Susan
• Format: Journal Article
• Language: English
• Published: France Wiley Subscription Services, Inc 01.03.2017
• Subjects: Alleles; Bipolar disorder; Cognitive ability; Cold pressing; Corticosteroids; Cortisol; Depression; Emotions; Female; FKBP5; Genotyping; Glucocorticoids; Heat shock proteins; Heterozygote; Hsp90 protein; Humans; Hypothalamus; Learning; Male; Memory; Mental depression; Mental disorders; Mental Recall; Pituitary; Polymorphism, Single Nucleotide; Post traumatic stress disorder; Receptor mechanisms; Saliva; Single-nucleotide polymorphism; stress; Stress, Psychological - genetics; Structure-function relationships; Tacrolimus; Tacrolimus Binding Proteins - genetics; Tacrolimus-binding protein; Young Adult; cortisol; stress; learning; memory; FKBP5

FK506 binding protein 51 (FKBP5) is a co‐chaperone of heat shock protein 90 and significantly influences glucocorticoid receptor sensitivity. Single nucleotide polymorphisms (SNPs) in the FKBP5 gene are associated with altered hypothalamus–pituitary–adrenal (HPA) axis function, changes in the struct...