Prolonged fecal shedding of SARS‐CoV‐2 in a young immunocompetent COVID‐19 patient: A case report and literature overview

Clinicians are facing several challenges in tackling coronavirus disease 2019 (COVID‐19); one issue is prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) RNA. Here, we describe a case of SARS‐CoV‐2 infection in a young immunocompetent patient with a virological cours...

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Published inJournal of medical virology Vol. 94; no. 7; pp. 3133 - 3137
Main Authors Xiao, Fang, Wan, Peiqi, Wei, Qiuling, Wei, Guiyang, Yu, Yanhong
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.07.2022
John Wiley and Sons Inc
Subjects
Antiviral drugs
Case reports
Coronaviruses
COVID-19
Feces
Glucocorticoids
Immunocompetence
immunocompetent
Immunosuppressive agents
Interferon
Patients
prolonged viral RNA shedding
Ribonucleic acid
RNA
SARS‐CoV‐2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Shedding
Viral diseases
Virology
COVID-19
immunocompetent
SARS-CoV-2
prolonged viral RNA shedding
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Abstract Clinicians are facing several challenges in tackling coronavirus disease 2019 (COVID‐19); one issue is prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) RNA. Here, we describe a case of SARS‐CoV‐2 infection in a young immunocompetent patient with a virological course lasting for 71 days. Following antiviral treatment, but no additional glucocorticoid or interferon therapy, the patient recovered from COVID‐19 pneumonia (moderate). Detection of viral RNA via throat swabs showed negative results. However, the viral RNA reappeared and persisted in stool samples for an additional 27 days, while the patient remained asymptomatic and exhibited no abnormal signs. This case indicates that SARS‐CoV‐2 can result in a prolonged fecal RNA shedding, even in an immunocompetent patient with zero exposure to immunosuppressive therapies.
AbstractList Clinicians are facing several challenges in tackling coronavirus disease 2019 (COVID‐19); one issue is prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) RNA. Here, we describe a case of SARS‐CoV‐2 infection in a young immunocompetent patient with a virological course lasting for 71 days. Following antiviral treatment, but no additional glucocorticoid or interferon therapy, the patient recovered from COVID‐19 pneumonia (moderate). Detection of viral RNA via throat swabs showed negative results. However, the viral RNA reappeared and persisted in stool samples for an additional 27 days, while the patient remained asymptomatic and exhibited no abnormal signs. This case indicates that SARS‐CoV‐2 can result in a prolonged fecal RNA shedding, even in an immunocompetent patient with zero exposure to immunosuppressive therapies.
Clinicians are facing several challenges in tackling coronavirus disease 2019 (COVID‐19); one issue is prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) RNA. Here, we describe a case of SARS‐CoV‐2 infection in a young immunocompetent patient with a virological course lasting for 71 days. Following antiviral treatment, but no additional glucocorticoid or interferon therapy, the patient recovered from COVID‐19 pneumonia (moderate). Detection of viral RNA via throat swabs showed negative results. However, the viral RNA reappeared and persisted in stool samples for an additional 27 days, while the patient remained asymptomatic and exhibited no abnormal signs. This case indicates that SARS‐CoV‐2 can result in a prolonged fecal RNA shedding, even in an immunocompetent patient with zero exposure to immunosuppressive therapies.
Clinicians are facing several challenges in tackling coronavirus disease 2019 (COVID-19); one issue is prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA. Here, we describe a case of SARS-CoV-2 infection in a young immunocompetent patient with a virological course lasting for 71 days. Following antiviral treatment, but no additional glucocorticoid or interferon therapy, the patient recovered from COVID-19 pneumonia (moderate). Detection of viral RNA via throat swabs showed negative results. However, the viral RNA reappeared and persisted in stool samples for an additional 27 days, while the patient remained asymptomatic and exhibited no abnormal signs. This case indicates that SARS-CoV-2 can result in a prolonged fecal RNA shedding, even in an immunocompetent patient with zero exposure to immunosuppressive therapies.Clinicians are facing several challenges in tackling coronavirus disease 2019 (COVID-19); one issue is prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA. Here, we describe a case of SARS-CoV-2 infection in a young immunocompetent patient with a virological course lasting for 71 days. Following antiviral treatment, but no additional glucocorticoid or interferon therapy, the patient recovered from COVID-19 pneumonia (moderate). Detection of viral RNA via throat swabs showed negative results. However, the viral RNA reappeared and persisted in stool samples for an additional 27 days, while the patient remained asymptomatic and exhibited no abnormal signs. This case indicates that SARS-CoV-2 can result in a prolonged fecal RNA shedding, even in an immunocompetent patient with zero exposure to immunosuppressive therapies.
Author Xiao, Fang
Wan, Peiqi
Yu, Yanhong
Wei, Qiuling
Wei, Guiyang
AuthorAffiliation 2 Department of Infectious Disease Guangxi Duan Yao Autonomous County People's Hospital Hechi China
1 Department of Infectious Disease The First Affiliated Hospital of Guangxi Medical University Nanning China
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CitedBy_id crossref_primary_10_24018_ejbiomed_2023_2_3_66
crossref_primary_10_3389_fmed_2022_959196
crossref_primary_10_1016_j_heha_2023_100056
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Keywords COVID-19
immunocompetent
SARS-CoV-2
prolonged viral RNA shedding
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Snippet Clinicians are facing several challenges in tackling coronavirus disease 2019 (COVID‐19); one issue is prolonged detection of severe acute respiratory syndrome...
Clinicians are facing several challenges in tackling coronavirus disease 2019 (COVID-19); one issue is prolonged detection of severe acute respiratory syndrome...
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SubjectTerms Antiviral drugs
Case reports
Coronaviruses
COVID-19
Feces
Glucocorticoids
Immunocompetence
immunocompetent
Immunosuppressive agents
Interferon
Patients
prolonged viral RNA shedding
Ribonucleic acid
RNA
SARS‐CoV‐2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Shedding
Viral diseases
Virology
Title Prolonged fecal shedding of SARS‐CoV‐2 in a young immunocompetent COVID‐19 patient: A case report and literature overview
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjmv.27694
https://www.ncbi.nlm.nih.gov/pubmed/35274321
https://www.proquest.com/docview/2665557938
https://www.proquest.com/docview/2638714304
https://pubmed.ncbi.nlm.nih.gov/PMC9088484
Volume 94
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