The actions of relaxin on the human cardiovascular system

• Published in: British journal of pharmacology Vol. 174; no. 10; pp. 933 - 949
• Main Authors: Sarwar, Mohsin, Du, Xiao‐Jun, Dschietzig, Thomas B, Summers, Roger J
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2017; John Wiley and Sons Inc
• Subjects: Angiogenesis; Animal models; Apoptosis; Cardiomyopathy; Cardiovascular diseases; Cardiovascular Diseases - drug therapy; Cardiovascular system; Cardiovascular System - drug effects; Clinical trials; Coronary artery disease; Cyclic GMP; Endothelin receptors; Endothelins; Females; Fibrosis; Gene expression; Growth factors; Heart diseases; Humans; Inflammation; Insulin; Ischemia; Males; Myocardial infarction; Peptides; Pregnancy; Relaxin; Relaxin - administration & dosage; Relaxin - pharmacology; Relaxin - therapeutic use; Reperfusion; Review; Signal transduction; Themed Section: Review

The insulin‐like peptide relaxin, originally identified as a hormone of pregnancy, is now known to exert a range of pleiotropic effects including vasodilatory, anti‐fibrotic, angiogenic, anti‐apoptotic and anti‐inflammatory effects in both males and females. Relaxin produces these effects by binding...