A functional haplotype of NFKB1 influence susceptibility to oral cancer: a population‐based and in vitro study

• Published in: Cancer medicine (Malden, MA) Vol. 7; no. 5; pp. 2211 - 2218
• Main Authors: Chen, Fa, Liu, Fengqiong, Yan, Lingjun, Lin, Lisong, Qiu, Yu, Wang, Jing, Wu, Junfeng, Bao, Xiaodan, Hu, Zhijian, Cai, Lin, He, Baochang
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.05.2018; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Aged; Aged, 80 and over; Binding sites; biological mechanism; Biomarkers, Tumor - genetics; Cancer Prevention; Carcinoma, Squamous Cell - genetics; Case-Control Studies; Cell Line, Tumor; Clonal deletion; Electrophoretic mobility; Electrophoretic Mobility Shift Assay; Female; Gene deletion; Genetic Association Studies; Genetic diversity; Genetic markers; Genetic Markers - genetics; Genetic Predisposition to Disease - genetics; haplotype; Haplotypes; Humans; Immunoglobulins; Linkage disequilibrium; Male; Middle Aged; Mouth Neoplasms - genetics; NF-kappa B p50 Subunit - genetics; NF-KappaB Inhibitor alpha - genetics; NFKB1; NFKBIA; Oral cancer; Original Research; Plasmids; Polymorphism, Single Nucleotide - genetics; Population-based studies; Promoter Regions, Genetic - genetics; Risk Factors; Squamous cell carcinoma; Tumor cell lines; Young Adult; Beijing China; China; NFKBIA; biological mechanism; haplotype; NFKB1; oral cancer

Genetic variations of NF‐κB and its inhibitor IκB genes and their biological mechanism in oral cancer were not well recognized. The purpose of this study was to evaluate the associations of polymorphisms in NFKB1 and NFKBIA with oral cancer susceptibility, and further explore their potential mechani...