Multiregional radiomics profiling from multiparametric MRI: Identifying an imaging predictor of IDH1 mutation status in glioblastoma

• Published in: Cancer medicine (Malden, MA) Vol. 7; no. 12; pp. 5999 - 6009
• Main Authors: Li, Zhi‐Cheng, Bai, Hongmin, Sun, Qiuchang, Zhao, Yuanshen, Lv, Yanchun, Zhou, Jian, Liang, Chaofeng, Chen, Yinsheng, Liang, Dong, Zheng, Hairong
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.12.2018; John Wiley and Sons Inc
• Subjects: Accuracy; Age; Aged; Brain cancer; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - genetics; Clinical Cancer Research; Edema; Female; Glioblastoma; Glioblastoma - diagnostic imaging; Glioblastoma - genetics; Humans; IDH1 mutation; Isocitrate dehydrogenase; Isocitrate Dehydrogenase - genetics; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Models, Biological; Mutation; NMR; Nuclear magnetic resonance; Original Research; Radiomics; China; Germany; IDH1 mutation; radiomics; magnetic resonance imaging; glioblastoma
• ISSN: 2045-7634; 2045-7634
• DOI: 10.1002/cam4.1863

Purpose Isocitrate dehydrogenase 1 (IDH1) has been proven as a prognostic and predictive marker in glioblastoma (GBM) patients. The purpose was to preoperatively predict IDH mutation status in GBM using multiregional radiomics features from multiparametric magnetic resonance imaging (MRI). Methods I...