The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis

• Published in: Hepatology (Baltimore, Md.) Vol. 67; no. 4; pp. 1284 - 1302
• Main Authors: Puri, Puneet, Liangpunsakul, Suthat, Christensen, Jeffrey E., Shah, Vijay H., Kamath, Patrick S., Gores, Gregory J., Walker, Susan, Comerford, Megan, Katz, Barry, Borst, Andrew, Yu, Qigui, Kumar, Divya P., Mirshahi, Faridoddin, Radaeva, Svetlana, Chalasani, Naga P., Crabb, David W., Sanyal, Arun J.
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.04.2018
• Subjects: Adult; Alcohol; Alcohol Drinking - adverse effects; Alcohol use; Bacteria; Biodegradation; Biofilms; Cell activation; Denitrification; Deoxyribonucleic acid; Discriminant analysis; DNA; DNA sequencing; DNA, Bacterial - blood; DNA, Bacterial - genetics; Drinking behavior; Dysbacteriosis; Endotoxemia; Endotoxins - blood; Female; Gram-negative bacteria; Hepatitis; Hepatitis, Alcoholic - microbiology; Hepatology; Humans; Intestine; Liver - microbiology; Liver - pathology; Liver diseases; Liver Diseases, Alcoholic - microbiology; Male; Metagenomics - methods; Methanogenesis; Mevalonic acid; Microbiomes; Microbiota - genetics; Middle Aged; Monocytes; Monocytes - pathology; Secretion; Virulence

Intestinal dysbiosis is implicated in alcoholic hepatitis (AH). However, changes in the circulating microbiome, its association with the presence and severity of AH, and its functional relevance in AH is unknown. Qualitative and quantitative assessment of changes in the circulating microbiome were p...