A Strategy to Treat COVID‐19 Disease With Targeted Delivery of Inhalable Liposomal Hydroxychloroquine: A Preclinical Pharmacokinetic Study - Tai, Tien‐Tzu; Wu, Tzung‐Ju; Wu, Huey‐Dong; Tsai, Yi‐Chen; Wang, Hui‐Ting; Wang, An‐Min; Shih, Sheue‐Fang; Chen, Yee‐Chun (Clinical and translational science, 2021)
Keywords: Administration, Inhalation; Animal models; Animals; Antiviral drugs; Brief Report; Cardiotoxicity; Clinical trials; Coronaviridae; Coronaviruses; COVID-19; COVID-19 - drug therapy; Disease; Dosage; Drug dosages; Female; Heart; Hydroxychloroquine; Hydroxychloroquine - administration & dosage; Hydroxychloroquine - adverse effects; Hydroxychloroquine - pharmacokinetics; Inflammation; Liposomes; Lung - metabolism; Lungs; Pandemics; Pharmacokinetics; Rats; Rats, Sprague-Dawley; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Trachea; United States--US; Taiwan