Identification of unique transcriptomic signatures and key genes through RNA sequencing and integrated WGCNA and PPI network analysis in HIV infected lung cancer

• Published in: Cancer medicine (Malden, MA) Vol. 12; no. 1; pp. 949 - 960
• Main Authors: Wu, Liwei, Chen, Yongfang, Wan, Laiyi, Wen, Zilu, Liu, Rong, Li, Leilei, Song, Yanzheng, Wang, Lin
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2023; John Wiley and Sons Inc; Wiley
• Subjects: Acquired immune deficiency syndrome; Acquired Immunodeficiency Syndrome; AIDS; Biomarkers; Cancer therapies; Cell Cycle Proteins - genetics; differential gene analysis; Gene expression; Gene Expression Profiling; Gene Regulatory Networks; Genotype & phenotype; Highly active antiretroviral therapy; HIV; HIV infected lung cancer; hub gene; Human immunodeficiency virus; Humans; Lung cancer; Lung Neoplasms - genetics; Mitosis; Ontology; Patients; Polo-like kinase 1; PPI; Proteins; Public health; Sequence Analysis, RNA; Survival; Transcriptome; Transcriptomics; WCGNA; PPI; hub gene; HIV infected lung cancer; WCGNA; differential gene analysis

With the widespread use of highly active antiretroviral therapy (HARRT), the survival time of AIDS patients has been greatly extended. However, the incidence of lung cancer in HIV‐infected patients is increasing and has become a major problem threatening the survival of AIDS patients. The aim of thi...