Identification of unique transcriptomic signatures and key genes through RNA sequencing and integrated WGCNA and PPI network analysis in HIV infected lung cancer
With the widespread use of highly active antiretroviral therapy (HARRT), the survival time of AIDS patients has been greatly extended. However, the incidence of lung cancer in HIV‐infected patients is increasing and has become a major problem threatening the survival of AIDS patients. The aim of thi...
Saved in:
Published in | Cancer medicine (Malden, MA) Vol. 12; no. 1; pp. 949 - 960 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
John Wiley & Sons, Inc
01.01.2023
John Wiley and Sons Inc Wiley |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | With the widespread use of highly active antiretroviral therapy (HARRT), the survival time of AIDS patients has been greatly extended. However, the incidence of lung cancer in HIV‐infected patients is increasing and has become a major problem threatening the survival of AIDS patients. The aim of this study is to use Weighted Gene Co‐expression Network Analysis (WGCNA) and differential gene analysis to find possible key genes involved in HIV‐infected lung cancer. In this study, using lung tissue samples from five pairs of HIV‐infected lung cancer patients, second‐generation sequencing was performed and transcriptomic data were obtained. A total of 132 HIV‐infected lung cancer‐related genes were screened out by WGCNA and differential gene expression analysis methods. Based on gene annotation analysis, these genes were mainly enriched in mitosis‐related functions and pathways. In addition, in protein–protein interaction (PPI) analysis, a total of 39 hub genes were identified. Among them, five genes (ASPM, CDCA8, CENPF, CEP55, and PLK1) were present in both three hub gene lists (intersection gene, DEGs, and WCGNA module) suggesting that these five genes may become key genes involved in HIV‐infected lung cancer.
1. This study reveals a unique transcriptomic profile of HIV‐infected lung cancer patients. 2.This study could point the way to studying the pathogenesis of lung cancer in HIV infection. |
---|---|
AbstractList | With the widespread use of highly active antiretroviral therapy (HARRT), the survival time of AIDS patients has been greatly extended. However, the incidence of lung cancer in HIV-infected patients is increasing and has become a major problem threatening the survival of AIDS patients. The aim of this study is to use Weighted Gene Co-expression Network Analysis (WGCNA) and differential gene analysis to find possible key genes involved in HIV-infected lung cancer. In this study, using lung tissue samples from five pairs of HIV-infected lung cancer patients, second-generation sequencing was performed and transcriptomic data were obtained. A total of 132 HIV-infected lung cancer-related genes were screened out by WGCNA and differential gene expression analysis methods. Based on gene annotation analysis, these genes were mainly enriched in mitosis-related functions and pathways. In addition, in protein-protein interaction (PPI) analysis, a total of 39 hub genes were identified. Among them, five genes (ASPM, CDCA8, CENPF, CEP55, and PLK1) were present in both three hub gene lists (intersection gene, DEGs, and WCGNA module) suggesting that these five genes may become key genes involved in HIV-infected lung cancer. With the widespread use of highly active antiretroviral therapy (HARRT), the survival time of AIDS patients has been greatly extended. However, the incidence of lung cancer in HIV‐infected patients is increasing and has become a major problem threatening the survival of AIDS patients. The aim of this study is to use Weighted Gene Co‐expression Network Analysis (WGCNA) and differential gene analysis to find possible key genes involved in HIV‐infected lung cancer. In this study, using lung tissue samples from five pairs of HIV‐infected lung cancer patients, second‐generation sequencing was performed and transcriptomic data were obtained. A total of 132 HIV‐infected lung cancer‐related genes were screened out by WGCNA and differential gene expression analysis methods. Based on gene annotation analysis, these genes were mainly enriched in mitosis‐related functions and pathways. In addition, in protein–protein interaction (PPI) analysis, a total of 39 hub genes were identified. Among them, five genes (ASPM, CDCA8, CENPF, CEP55, and PLK1) were present in both three hub gene lists (intersection gene, DEGs, and WCGNA module) suggesting that these five genes may become key genes involved in HIV‐infected lung cancer. 1. This study reveals a unique transcriptomic profile of HIV‐infected lung cancer patients. 2.This study could point the way to studying the pathogenesis of lung cancer in HIV infection. Abstract With the widespread use of highly active antiretroviral therapy (HARRT), the survival time of AIDS patients has been greatly extended. However, the incidence of lung cancer in HIV‐infected patients is increasing and has become a major problem threatening the survival of AIDS patients. The aim of this study is to use Weighted Gene Co‐expression Network Analysis (WGCNA) and differential gene analysis to find possible key genes involved in HIV‐infected lung cancer. In this study, using lung tissue samples from five pairs of HIV‐infected lung cancer patients, second‐generation sequencing was performed and transcriptomic data were obtained. A total of 132 HIV‐infected lung cancer‐related genes were screened out by WGCNA and differential gene expression analysis methods. Based on gene annotation analysis, these genes were mainly enriched in mitosis‐related functions and pathways. In addition, in protein–protein interaction (PPI) analysis, a total of 39 hub genes were identified. Among them, five genes (ASPM, CDCA8, CENPF, CEP55, and PLK1) were present in both three hub gene lists (intersection gene, DEGs, and WCGNA module) suggesting that these five genes may become key genes involved in HIV‐infected lung cancer. |
Author | Wan, Laiyi Song, Yanzheng Wu, Liwei Wen, Zilu Liu, Rong Li, Leilei Wang, Lin Chen, Yongfang |
AuthorAffiliation | 2 Department of Pharmacy Shanghai Public Health Clinical Center Shanghai China 1 Department of Thoracic Surgery Shanghai Public Health Clinical Center, Fudan University Shanghai Shanghai China 4 TB Center Shanghai Emerging and Re‐emerging Infectious Disease Institute, Fudan University Shanghai China 3 Department of Scientific Research Shanghai Public Health Clinical Center, Fudan University Shanghai China |
AuthorAffiliation_xml | – name: 2 Department of Pharmacy Shanghai Public Health Clinical Center Shanghai China – name: 3 Department of Scientific Research Shanghai Public Health Clinical Center, Fudan University Shanghai China – name: 1 Department of Thoracic Surgery Shanghai Public Health Clinical Center, Fudan University Shanghai Shanghai China – name: 4 TB Center Shanghai Emerging and Re‐emerging Infectious Disease Institute, Fudan University Shanghai China |
Author_xml | – sequence: 1 givenname: Liwei orcidid: 0000-0002-3150-2260 surname: Wu fullname: Wu, Liwei organization: Shanghai Public Health Clinical Center, Fudan University Shanghai – sequence: 2 givenname: Yongfang surname: Chen fullname: Chen, Yongfang organization: Shanghai Public Health Clinical Center – sequence: 3 givenname: Laiyi surname: Wan fullname: Wan, Laiyi organization: Shanghai Public Health Clinical Center, Fudan University Shanghai – sequence: 4 givenname: Zilu surname: Wen fullname: Wen, Zilu organization: Shanghai Public Health Clinical Center, Fudan University – sequence: 5 givenname: Rong surname: Liu fullname: Liu, Rong organization: Shanghai Public Health Clinical Center – sequence: 6 givenname: Leilei surname: Li fullname: Li, Leilei organization: Shanghai Public Health Clinical Center, Fudan University Shanghai – sequence: 7 givenname: Yanzheng surname: Song fullname: Song, Yanzheng email: yanzhengsong@163.com organization: Shanghai Emerging and Re‐emerging Infectious Disease Institute, Fudan University – sequence: 8 givenname: Lin surname: Wang fullname: Wang, Lin email: wlxxs2011@163.com organization: Shanghai Emerging and Re‐emerging Infectious Disease Institute, Fudan University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35608130$$D View this record in MEDLINE/PubMed |
BookMark | eNp1ks1uEzEQgC1UREvogRdAlrjAIa13_bO7F6QogjZSgQrxc7Qce3bjdGMH20uVx-FN8SalapHwxZ7x50-j8TxHR847QOhlQc4KQspzrTbsjNWcPkEnJWF8WgnKjh6cj9FpjGuSV0VKURXP0DHlgtQFJSfo98KAS7a1WiXrHfYtHpz9OQBOQbmog90mv7EaR9s5lYYAEStn8A3scAcuR2kV_NCt8JdPMxwhv3Taum4PWZegCyqBwT8u5vl-TF5fL7CDdOvDTY5Vv4s2ZhJfLr7nrQU94v2QFVo5DeEFetqqPsLp3T5B3z68_zq_nF59vljMZ1dTzUlDp4KXZVNWbcsV54aYUjRGM8EUNXVOMap5Xda8JgS0JqLguRdEK6WNMKUhSzpBi4PXeLWW22A3KuykV1buEz50UoVkdQ-SCqoAmroVrGBGwVIwUrUGdEVqTtrR9e7g2g7LDRidWxxU_0j6-MbZlez8L9nULNfcZMGbO0HwuaUxyY2NGvpeOfBDlKUQdVOQMlcyQa__Qdd-CLmxmapE_mdGK5qptwdKBx9jgPa-mILIcY7kOEdynKPMvnpY_T35d2oycH4Abm0Pu_-b5Hz2ke2VfwC-5NU8 |
CitedBy_id | crossref_primary_10_1016_j_canlet_2024_216739 crossref_primary_10_1016_j_tranon_2023_101819 crossref_primary_10_18632_aging_205783 |
Cites_doi | 10.3390/ijms22158127 10.3390/ijms22010042 10.1016/s2352-3018(20)30232-0 10.1159/000495205 10.1093/nar/gkaa970 10.1186/1471-2105-12-35 10.1093/abbs/gmab118 10.1186/1471-2105-9-559 10.2147/ott.S226921 10.1038/s41598-019-53471-0 10.1016/j.prp.2021.153459 10.3389/fgene.2019.00214 10.2147/jir.S340452 10.1093/bioinformatics/btp616 10.6004/jnccn.2021.0013 10.1111/jcmm.16264 10.1371/journal.pbio.3001419 10.1093/nar/gkaa1074 10.3390/cancers13051055 10.1016/j.bcp.2021.114747 10.1186/s12859-019-2657-0 10.3390/cancers11111725 10.1021/acs.jproteome.8b00702 10.1089/dna.2020.6457 10.1016/j.lungcan.2020.07.007 10.1111/jcmm.15435 10.1016/j.celrep.2021.109343 10.1093/bioinformatics/btv300 10.1093/nar/gkv007 10.3390/cancers13174413 10.1002/ijc.32730 10.1089/omi.2011.0118 10.1186/1752-0509-8-s4-s11 10.1093/nar/gkj021 10.3322/caac.21660 |
ContentType | Journal Article |
Copyright | 2022 The Authors. published by John Wiley & Sons Ltd. 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: 2022 The Authors. published by John Wiley & Sons Ltd. – notice: 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. – notice: 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
DBID | 24P WIN CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M7P PIMPY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
DOI | 10.1002/cam4.4853 |
DatabaseName | Wiley Online Library Open Access Wiley Online Library Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) Biological Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE Publicly Available Content Database CrossRef |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 24P name: Open Access: Wiley-Blackwell Open Access Journals url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Public Health |
DocumentTitleAlternate | Wu et al |
EISSN | 2045-7634 |
EndPage | 960 |
ExternalDocumentID | oai_doaj_org_article_363aee98f6414daeb6407fdec70850fb 10_1002_cam4_4853 35608130 CAM44853 |
Genre | article Research Support, Non-U.S. Gov't Journal Article |
GrantInformation_xml | – fundername: The Shanghai Public Health Clinical Center fund funderid: KY‐GW‐2021‐49 – fundername: The Shanghai Public Health Clinical Center fund grantid: KY‐GW‐2021‐49 |
GroupedDBID | 0R~ 1OC 24P 31~ 53G 5VS 7X7 8-0 8-1 8FE 8FH 8FI 8FJ AAHHS AAZKR ABDBF ABUWG ACCFJ ACXQS ADBBV ADKYN ADRAZ ADZMN ADZOD AEEZP AENEX AEQDE AFKRA AIWBW AJBDE ALAGY ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AOIJS AVUZU BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CCPQU D-8 D-9 DIK EBS EJD FYUFA GODZA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE HZ~ IAO IHR KQ8 LK8 M48 M7P M~E O9- OK1 OVD PIMPY PQQKQ PROAC RPM TEORI TUS UKHRP WIN CGR CUY CVF ECM EIF ITC NPM AAYXX ADPDF CITATION 3V. 7XB 8FK AZQEC DWQXO GNUQQ K9. PQEST PQUKI PRINS 7X8 5PM ACUHS |
ID | FETCH-LOGICAL-c5093-6522927ff5a55d0d269dc464a3d85a543c58285800ecc06150260caacd6d2d0b3 |
IEDL.DBID | RPM |
ISSN | 2045-7634 |
IngestDate | Tue Dec 17 15:16:46 EST 2024 Tue Sep 17 21:30:30 EDT 2024 Fri Oct 25 05:43:35 EDT 2024 Thu Oct 10 19:02:38 EDT 2024 Fri Dec 06 05:24:53 EST 2024 Sat Sep 28 08:22:24 EDT 2024 Sat Aug 24 01:07:58 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | PPI hub gene HIV infected lung cancer WCGNA differential gene analysis |
Language | English |
License | Attribution 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c5093-6522927ff5a55d0d269dc464a3d85a543c58285800ecc06150260caacd6d2d0b3 |
Notes | Liwei Wu, Yongfang Chen, and Laiyi Wan contributed equally to this work. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0002-3150-2260 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844649/ |
PMID | 35608130 |
PQID | 2766084373 |
PQPubID | 2032540 |
PageCount | 12 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_363aee98f6414daeb6407fdec70850fb pubmedcentral_primary_oai_pubmedcentral_nih_gov_9844649 proquest_miscellaneous_2668910236 proquest_journals_2766084373 crossref_primary_10_1002_cam4_4853 pubmed_primary_35608130 wiley_primary_10_1002_cam4_4853_CAM44853 |
PublicationCentury | 2000 |
PublicationDate | January 2023 |
PublicationDateYYYYMMDD | 2023-01-01 |
PublicationDate_xml | – month: 01 year: 2023 text: January 2023 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: Bognor Regis – name: Hoboken |
PublicationTitle | Cancer medicine (Malden, MA) |
PublicationTitleAlternate | Cancer Med |
PublicationYear | 2023 |
Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
Publisher_xml | – sequence: 0 name: Wiley – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc |
References | 2021; 25 2021; 8 2021; 49 2019; 9 2021; 22 2006; 34 2021; 223 2019; 11 2019; 10 2015; 31 2019; 12 2008; 9 2019; 18 2011; 12 2020; 146 2012; 16 2020; 147 2021; 71 2021; 14 2021; 36 2021; 13 2010; 26 2021; 53 2019; 20 2021; 19 2015; 43 2021; 193 2020; 24 2018; 51 2020; 22 2014; 8 2021; 40 e_1_2_9_30_1 e_1_2_9_31_1 e_1_2_9_11_1 e_1_2_9_34_1 e_1_2_9_10_1 e_1_2_9_35_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_12_1 e_1_2_9_33_1 e_1_2_9_15_1 e_1_2_9_14_1 e_1_2_9_17_1 e_1_2_9_36_1 e_1_2_9_16_1 e_1_2_9_19_1 e_1_2_9_18_1 e_1_2_9_20_1 e_1_2_9_22_1 e_1_2_9_21_1 e_1_2_9_24_1 e_1_2_9_23_1 e_1_2_9_8_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_5_1 e_1_2_9_4_1 e_1_2_9_3_1 e_1_2_9_2_1 e_1_2_9_9_1 e_1_2_9_26_1 e_1_2_9_25_1 e_1_2_9_28_1 e_1_2_9_27_1 e_1_2_9_29_1 |
References_xml | – volume: 51 start-page: 244 issue: 1 year: 2018 end-page: 261 article-title: Weighted Gene Correlation Network Analysis (WGCNA) detected loss of MAGI2 promotes Chronic Kidney Disease (CKD) by podocyte damage publication-title: Cell Physiol Biochem – volume: 31 start-page: 2912 issue: 17 year: 2015 end-page: 2914 article-title: GOplot: an R package for visually combining expression data with functional analysis publication-title: Bioinformatics – volume: 13 issue: 5 year: 2021 article-title: Silencing CDCA8 suppresses hepatocellular carcinoma growth and stemness via restoration of ATF3 tumor suppressor and inactivation of AKT/β‐catenin signaling publication-title: Cancer – volume: 9 issue: 1 year: 2019 article-title: Feature selection with the fisher score followed by the maximal clique centrality algorithm can accurately identify the hub genes of hepatocellular carcinoma publication-title: Sci Rep – volume: 40 start-page: 921 issue: 7 year: 2021 end-page: 935 article-title: ASPM is a Novel candidate gene associated with colorectal cancer cell growth publication-title: DNA Cell Biol – volume: 193 year: 2021 article-title: Polo‐like kinase 1 (PLK1) signaling in cancer and beyond publication-title: Biochem Pharmacol – volume: 147 start-page: 154 year: 2020 end-page: 186 article-title: Risk‐Based lung cancer screening: a systematic review publication-title: Lung Cancer – volume: 146 start-page: 2666 issue: 10 year: 2020 end-page: 2679 article-title: HIV‐1, HAART and cancer: a complex relationship publication-title: Int J Cancer – volume: 19 issue: 10 year: 2021 article-title: A field guide to cultivating computational biology publication-title: PLoS Biol – volume: 53 start-page: 1398 issue: 10 year: 2021 end-page: 1407 article-title: Inhibition of miR‐144‐3p exacerbates non‐small cell lung cancer progression by targeting CEP55 publication-title: Acta Biochim Biophys Sin (Shanghai) – volume: 19 start-page: 254 issue: 3 year: 2021 end-page: 266 article-title: NCCN guidelines insights: non‐small cell lung cancer, version 2.2021 publication-title: J Natl Compr Canc Netw – volume: 8 start-page: e51 issue: 1 year: 2021 end-page: e58 article-title: The case for an HIV cure and how to get there publication-title: Lancet HIV – volume: 34 start-page: D322 year: 2006 end-page: D326 article-title: The Gene Ontology (GO) project in 2006 publication-title: Nucleic Acids Res – volume: 223 year: 2021 article-title: miR‐133b inhibits cell proliferation, migration, and invasion of lung adenocarcinoma by targeting CDCA8 publication-title: Pathol Res Pract – volume: 49 start-page: D605 year: 2021 end-page: D612 article-title: The STRING database in 2021: customizable protein‐protein networks, and functional characterization of user‐uploaded gene/measurement sets publication-title: Nucleic Acids Res – volume: 20 start-page: 81 issue: 1 year: 2019 article-title: Functional Heatmap: an automated and interactive pattern recognition tool to integrate time with multi‐omics assays publication-title: BMC Bioinformatics – volume: 8 issue: Suppl 4 year: 2014 article-title: cytoHubba: identifying hub objects and sub‐networks from complex interactome publication-title: BMC Syst Biol – volume: 22 issue: 1 year: 2020 article-title: Infections and Immunotherapy in Lung Cancer: A Bad Relationship? publication-title: Int J Mol Sci – volume: 10 start-page: 214 year: 2019 article-title: Recent advances of deep learning in bioinformatics and computational biology publication-title: Front Genet – volume: 49 start-page: D545 year: 2021 end-page: D551 article-title: KEGG: integrating viruses and cellular organisms publication-title: Nucleic Acids Res – volume: 11 issue: 11 year: 2019 article-title: Comprehensive outline of whole exome sequencing data analysis tools available in clinical oncology publication-title: Cancer – volume: 24 start-page: 9613 issue: 17 year: 2020 end-page: 9626 article-title: Aberrant ASPM expression mediated by transcriptional regulation of FoxM1 promotes the progression of gliomas publication-title: J Cell Mol Med – volume: 13 issue: 17 year: 2021 article-title: Dual targeting of EGFR with PLK1 exerts therapeutic synergism in taxane‐resistant lung adenocarcinoma by suppressing ABC transporters publication-title: Cancer – volume: 71 start-page: 209 issue: 3 year: 2021 end-page: 249 article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J Clin – volume: 16 start-page: 284 issue: 5 year: 2012 end-page: 287 article-title: clusterProfiler: an R package for comparing biological themes among gene clusters publication-title: OMICS – volume: 22 issue: 15 year: 2021 article-title: HIV‐associated cancer biomarkers: a requirement for early diagnosis publication-title: Int J Mol Sci – volume: 9 year: 2008 article-title: WGCNA: an R package for weighted correlation network analysis publication-title: BMC Bioinformatics – volume: 12 start-page: 11465 year: 2019 end-page: 11474 article-title: MiR‐195‐5p inhibits proliferation and induces apoptosis of non‐small cell lung cancer cells by targeting CEP55 publication-title: Onco Targets Ther – volume: 25 start-page: 1633 issue: 3 year: 2021 end-page: 1644 article-title: Construction of co‐expression modules related to survival by WGCNA and identification of potential prognostic biomarkers in glioblastoma publication-title: J Cell Mol Med – volume: 26 start-page: 139 issue: 1 year: 2010 end-page: 140 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics – volume: 14 start-page: 6143 year: 2021 end-page: 6156 article-title: Identification of unique transcriptomic signatures and hub genes through RNA sequencing and integrated WGCNA and PPI network analysis in nonerosive reflux disease publication-title: J Inflamm Res – volume: 18 start-page: 623 issue: 2 year: 2019 end-page: 632 article-title: Cytoscape stringapp: network analysis and visualization of proteomics data publication-title: J Proteome Res – volume: 36 issue: 2 year: 2021 article-title: Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation publication-title: Cell Rep – volume: 12 year: 2011 article-title: VennDiagram: a package for the generation of highly‐customizable Venn and Euler diagrams in R publication-title: BMC Bioinformatics – volume: 43 issue: 7 year: 2015 article-title: limma powers differential expression analyses for RNA‐sequencing and microarray studies publication-title: Nucleic Acids Res – ident: e_1_2_9_4_1 doi: 10.3390/ijms22158127 – ident: e_1_2_9_8_1 doi: 10.3390/ijms22010042 – ident: e_1_2_9_3_1 doi: 10.1016/s2352-3018(20)30232-0 – ident: e_1_2_9_12_1 doi: 10.1159/000495205 – ident: e_1_2_9_23_1 doi: 10.1093/nar/gkaa970 – ident: e_1_2_9_20_1 doi: 10.1186/1471-2105-12-35 – ident: e_1_2_9_32_1 doi: 10.1093/abbs/gmab118 – ident: e_1_2_9_16_1 doi: 10.1186/1471-2105-9-559 – ident: e_1_2_9_33_1 doi: 10.2147/ott.S226921 – ident: e_1_2_9_27_1 doi: 10.1038/s41598-019-53471-0 – ident: e_1_2_9_30_1 doi: 10.1016/j.prp.2021.153459 – ident: e_1_2_9_11_1 doi: 10.3389/fgene.2019.00214 – ident: e_1_2_9_13_1 doi: 10.2147/jir.S340452 – ident: e_1_2_9_15_1 doi: 10.1093/bioinformatics/btp616 – ident: e_1_2_9_7_1 doi: 10.6004/jnccn.2021.0013 – ident: e_1_2_9_14_1 doi: 10.1111/jcmm.16264 – ident: e_1_2_9_10_1 doi: 10.1371/journal.pbio.3001419 – ident: e_1_2_9_24_1 doi: 10.1093/nar/gkaa1074 – ident: e_1_2_9_31_1 doi: 10.3390/cancers13051055 – ident: e_1_2_9_36_1 doi: 10.1016/j.bcp.2021.114747 – ident: e_1_2_9_19_1 doi: 10.1186/s12859-019-2657-0 – ident: e_1_2_9_9_1 doi: 10.3390/cancers11111725 – ident: e_1_2_9_25_1 doi: 10.1021/acs.jproteome.8b00702 – ident: e_1_2_9_28_1 doi: 10.1089/dna.2020.6457 – ident: e_1_2_9_2_1 doi: 10.1016/j.lungcan.2020.07.007 – ident: e_1_2_9_29_1 doi: 10.1111/jcmm.15435 – ident: e_1_2_9_35_1 doi: 10.1016/j.celrep.2021.109343 – ident: e_1_2_9_18_1 doi: 10.1093/bioinformatics/btv300 – ident: e_1_2_9_17_1 doi: 10.1093/nar/gkv007 – ident: e_1_2_9_34_1 doi: 10.3390/cancers13174413 – ident: e_1_2_9_5_1 doi: 10.1002/ijc.32730 – ident: e_1_2_9_21_1 doi: 10.1089/omi.2011.0118 – ident: e_1_2_9_26_1 doi: 10.1186/1752-0509-8-s4-s11 – ident: e_1_2_9_22_1 doi: 10.1093/nar/gkj021 – ident: e_1_2_9_6_1 doi: 10.3322/caac.21660 |
SSID | ssj0000702671 |
Score | 2.3295896 |
Snippet | With the widespread use of highly active antiretroviral therapy (HARRT), the survival time of AIDS patients has been greatly extended. However, the incidence... Abstract With the widespread use of highly active antiretroviral therapy (HARRT), the survival time of AIDS patients has been greatly extended. However, the... |
SourceID | doaj pubmedcentral proquest crossref pubmed wiley |
SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 949 |
SubjectTerms | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome AIDS Biomarkers Cancer therapies Cell Cycle Proteins - genetics differential gene analysis Gene expression Gene Expression Profiling Gene Regulatory Networks Genotype & phenotype Highly active antiretroviral therapy HIV HIV infected lung cancer hub gene Human immunodeficiency virus Humans Lung cancer Lung Neoplasms - genetics Mitosis Ontology Patients Polo-like kinase 1 PPI Proteins Public health Sequence Analysis, RNA Survival Transcriptome Transcriptomics WCGNA |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LbxMxELZQD4gLAspjoVQGceCydNf2-nFMI9oUKVWFKPRmef0AJNigNvlB_FNm7E2UCBAXbmt7Dl7Pw5_t8WdCXhntIuMx1Uo6UwvhNfgcF1D0fWqNMm3CC87zczm7FO-uuqutp74wJ6zQA5eBO-KSuxiNTlK0IrjY48lTCtErJFtLfY6-DdtaTOUYrPBlpXZNJdSwI---izdCd3xnAso8_X8Cl7_nSG5j1zz5nNwjd0fUSCelt_fJrTg8ILfn47n4PvlZ7tumcQOOLhJdZWZWusS5KEcGvH5MMV0jU3neUDcECh5MP2O0o-N7PfT9-YSO6dUwqWWhDaNEoJ9Op9COlRcXZ3QoKeRQLsQmIElnZx9pSfAC8W8QSahHu7p-SC5P3n6Yzurx8YXaA4bgtQRgZphKqXNdF5rApAleSOF40FAluMcDtw7wJhhBppWHlZF3zgcZWGh6_ojsDYshPiE0qN7zTishUytUY5yIKapkjDewPGtFRV6uNWJ_FI4NW9iUmUW1WVRbRY5RVxsBpMXOFWAsdjQW-y9jqcjBWtN29NUby5SUjUaKp4q82DSDl-HRiRviYgUyUmqDLBeyIo-LYWx6wgE0aoACFVE7JrPT1d2W4euXzORtNKzGhanI62xcf_97O53MBX48_R_D8IzcYfAvZSfpgOwtr1fxOWCrZX-Y3egXKmskWg priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagSAgJIShQAgUZxIFLaBI7dnxCy4qyRdqqQhT2Fjl-FCRIyj5-EP-UGdsbWPG4xfYcHM3TM-PPhDxXjXYVcz6XQqucc9OAzjEOQ9P5UklVerzgPD8Vs3P-blEvUsJtldoqtzYxGGo7GMyRH1VSiKJBIJ5Xl99zfDUKq6vpCY2r5FpZgSsHeZYLOeZYQJwrIcstoFBRHRn9jb_kTc123FBA6_9biPlnp-TvEWxwQce3ya0UO9JJZPYdcsX1--T6PFXH98nNmIOj8WrRXfIj3sL1KS1HB083Aa-VrtFDBXuBl5IpNnEEgM8V1b2loNf0Am0gTa_40PenE5qarsHVBaIRZ8LST2-nsI6TZ2cntI-N5TCOcCdASWcnH2ls-wLyr2BfqEFpW94j58dvPkxneXqSITcQWbBcQLimKul9revaFrYSyhouuGa2gSnODJbhaohCQTQC2Dycl4zWxgpb2aJj98leP_TuAaFWdobVjeTCl1wWSnPnnfRKGQWHtpJn5NmWQ-1lRN5oI8Zy1SIbW2RjRl4j70YCBMsOE8Pyok261zLBtHOq8YKX3GrXYfHSW2ck4vX5LiOHW863SYNX7S95y8jTcRl0DwsqunfDBmiEaBRiX4iMHERBGXfCIJRsIEDIiNwRoZ2t7q70Xz4HfG_VwBmdq4y8CML2779vp5M5x4-H__-DR-RGBbuMmaNDsrdebtxjiKXW3ZOgMD8BXO0f8w priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED-NIU17QXwTGMggHnjpaGLHjh8QKhWjQ-o0IQp7ixx_DKSRQtdK8Ofwn3LnOFUrxgtvsX1R7Nyd72yffwfwXFfGF9yHgZJGD4SwFeocF1i0Tci10nmgC87TEzmZifdn5dkO9Dk20w-8vHJpR_mkZouLw58_fr1GhX-VAERfWvNNHAq0O9fgeoEGkSK7psnLjxOyojRLeY8rtPnGPuxxtPlVTlHQG4Yp4vdf5XT-HTu56dNGo3R0E24kb5KNOvbfgh3f3oa9aTovvwO_u3u4IW3MsXlgq4jYypZko-KMQdeSGYVxRIjPS2Zax1Cz2TnNgizl8WEfTkYshV2jsYtEa6QJxz6_G2M7VZ6eHrO2Cy3Hcgd4gpRscvyJdYFfSH6BMwyzJG-LuzA7evtxPBmkpAwDi74FH0h02HShQihNWbqhK6R2VkhhuKuwSnBLB3El-qEoHBFuHldM1hjrpCvcsOH3YLedt_4BMKcay8tKCRlyoYbaCB-8Clpbjcu2XGTwrOdI_b3D3qg7lOWiJg7WxMEM3hCv1gQElx0r5ovzOmlfzSU33usqSJELZ3xDx5fBeasIsS80GRz0nK57EawLJVEyCPopg6frZtQ-OlIxrZ-vkEbKShP6hczgficY6570gpWB2hKZra5ut7Rfv0SEb13hKl3oDF5E4fr36OvxaCro4eF_f-QR7Bc4gG5b6QB2l4uVf4yO1rJ5EtXoD4pNKgw priority: 102 providerName: Scholars Portal – databaseName: Wiley Online Library Open Access dbid: 24P link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwEB6VIiEuiDeBggziwCU0sR07FqdlRdkibbVCFHqLHD8KEmTRPn4Q_5QZJxtYARK32J4ojmbG89kefwZ4bmobuAgx18qaXEpXo88JiUXXxtJoU0Y64Dw_U7Nz-e6iujiAV7uzMD0_xLjgRp6RxmtycNuuj3-Rhjr7Tb6UGG2uwFWENYquL-ByMS6woC1zlSZcxLiOHxdyxyxU8OPx7b14lGj7_4Y1_0yZ_B3Kplh0chNuDCCSTXqt34KD0N2Ga_Nhm_wO_OiP38ZhPY4tI9smola2odCUBgo6jcwoeyMxe66Z7TxDh2aXNPix4foe9v5swoZsa4xxSWgkmPDs09sptlPlYnHKuj6jHMs9zwlKstnpR9bne6H4VxxYmCMzW92F85M3H6azfLiLIXcIKUSuEKcZrmOsbFX5wnNlvJNKWuFrrJLC0f5bhfATbSKxzONEyVnrvPLcF624B4fdsgsPgHndOlHVWqpYSl0YK0MMOhrjDM7WSpnBs51Gmu895UbTkyvzhtTWkNoyeE26GgWIJTtVLFeXzeB0jVDChmDqqGQpvQ0t7VpGH5wmor7YZnC003QzuO664VqpoibGpwyejs3odLSTYruw3KKMUrUh0guVwf3eMMaeCMSQNSKDDPSeyex1db-l-_I5EXubGifn0mTwIhnXv_--mU7mkh4e_r_oI7jOscf98tERHG5W2_AYAdWmfZIc5yf7fxzJ priority: 102 providerName: Wiley-Blackwell |
Title | Identification of unique transcriptomic signatures and key genes through RNA sequencing and integrated WGCNA and PPI network analysis in HIV infected lung cancer |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcam4.4853 https://www.ncbi.nlm.nih.gov/pubmed/35608130 https://www.proquest.com/docview/2766084373 https://search.proquest.com/docview/2668910236 https://pubmed.ncbi.nlm.nih.gov/PMC9844649 https://doaj.org/article/363aee98f6414daeb6407fdec70850fb |
Volume | 12 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED-aDkpfxr7nrQva2MNenMS2LFmPaWibDhxMWbe8GVkfXaFxSpr8Qf1Pe5LtkLDtZS8ilg4i-36nO0mnnwC-ikyaODE25EyKkFKVoc0lFB9VZSPBRWTdAed8xqbX9Ps8nR9A2p2F8Un7qrod1HeLQX372-dW3i_UsMsTGxb5RGQ4iaFi2IMeut-dKboffrm7VCnqWIRG8VDJBR1Q9EvHcJSgh88il_O844Y8W__fQsw_MyV3I1jvgs5fwPM2diTjpo8v4cDUr-Aob3fHX8Njc-rWtstwZGnJxvOzkrXzSH58cIeQiUva8ISeD0TWmqAdkxs35pH21h5yNRuTNskaXZsX2vJKaPLrYoLtrrIoLkndJJLjc0NvgpJkevmTNGleKH6H4wlRDl2rN3B9fvZjMg3bKxhChZFEEjIMz0TMrU1lmuqRjpnQCr-9THSGVTRRbtstxagToeDJ5XF-pKRUmulYj6rkLRzWy9q8B6J5pZI045TZiPKRkNRYw60QSuAkLaIBfOk0Ut43TBtlw6kcl06DpdNgAKdOV1sBR47tK5arm7KFSJmwRBojMstoRLU0ldustNoo7vj5bBXASafpsrXYhzLmDJHhiJ4C-LxtRltzGyiyNssNyjCWCcd1wQJ41wBj25MOWAHwPcjsdXW_BeHt-bxbOAfwzYPr329fTsY5dT8-_PeffITjGF-gWUQ6gcP1amM-YVi1rvrQi2mBJZ_zPjw7PZsVV32_RIHlxTzCMqdZ3xvbE_ZRKh4 |
link.rule.ids | 230,314,727,780,784,864,885,2102,2221,11562,12056,21388,24318,27924,27925,31719,31720,33744,33745,43310,43805,46052,46476,50814,50923,53791,53793,73745,74302 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bb9MwFLagkwAJIRi3wACDeOAlWxI7dvyEumqjhbWqpg32Fjm-DCRIRy8_iH_KObFbqLi8xfZ5cHQuPj6Xz4S8VpV2BXM-lUKrlHNTgc4xDkPT-FxJlXtscB5PxPCcv78oL2LAbRHLKtc2sTPUdmYwRn5QSCGyCoF43l59T_HVKMyuxic0rpMdRE4ve2Tn8GgyPd1EWUCgCyHzNaRQVhwY_Y3v86pkWwdRh9f_Nyfzz1rJ333Y7hA6vkvuRO-R9gO775Frrt0lN8YxP75LbocoHA3NRffJj9CH62Ngjs48XXWIrXSJZ1RnMbAtmWIZRwfxuaC6tRQ0m16iFaTxHR96OunTWHYNh11HtEGasPTTuwGs4-R0OqJtKC2HcQA8AUo6HH2kofALyL-ChaEG5W3-gJwfH50Nhml8lCE14FuwVIDDpgrpfanL0ma2EMoaLrhmtoIpzgwm4krwQ0E4Orh5uDEZrY0VtrBZwx6SXjtr3WNCrWwMKyvJhc-5zJTmzjvplTIKrm05T8irNYfqq4C9UQeU5aJGNtbIxoQcIu82BAiX3U3M5pd11L6aCaadU5UXPOdWuwbTl946IxGxzzcJ2Vtzvo46vKh_SVxCXm6WQfswpaJbN1sBjRCVQvQLkZBHQVA2O2HgTFbgIiREbonQ1la3V9ovnzuEb1XBLZ2rhLzphO3ff18P-mOOH0_-_wcvyM3h2fikPhlNPjwltwrYcYgj7ZHecr5yz8CzWjbPo_r8BOkYJEk |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lj9MwEB5BV1ohIQTLK7CAQRy4hCaxY8cn1C27tECrasXC3iLHjwUJ0qWPH8Q_Zey4hYrHLbbn4Gienhl_BnguK2ULal0quJIpY7pCnaMMh7pxuRQyd_6C82TKR2fs7Xl5HvuflrGtcmMTg6E2c-1z5P1CcJ5VHoin72JbxOz1yavL76l_QcpXWuNzGldhD71iVvRg7-h4OjvdZlxQuAsu8g28UFb0tfrGXrKqpDtOKWD3_y3g_LNv8vd4Njikk5twI0aSZNCx_hZcse0B7E9irfwArncZOdJdNLoNP7o7uS4m6cjckXVAbyUr76-C9fBXlIlv6Qhwn0uiWkNQy8mFt4gkvulDTqcDEluw0fEFoi3qhCGf3gxx3U_OZmPSdm3mOO7AT5CSjMYfSdcEhuRf0doQ7WVvcQfOTo4_DEdpfKAh1Rhn0JRj8CYL4VypytJkpuDSaMaZoqbCKUa1L8qVGJOioAToeTw9aaW04aYwWUPvQq-dt_Y-ECMaTctKMO5yJjKpmHVWOCm1xCNczhJ4tuFQfdnhcNQd4nJRezbWno0JHHnebQk8dHaYmC8u6qiJNeVUWSsrx1nOjLKNL2U6Y7Xw6H2uSeBww_k66vOy_iV9CTzdLqMm-vKKau18jTScV9IjYfAE7nWCst0JxcCywnAhAbEjQjtb3V1pv3wOaN-ywhM7kwm8CML277-vh4MJ8x8P_v8HT2AfNad-P56-ewjXCtxwl1I6hN5qsbaPMMhaNY-j9vwEe_Modg |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Identification+of+unique+transcriptomic+signatures+and+key+genes+through+RNA+sequencing+and+integrated+WGCNA+and+PPI+network+analysis+in+HIV+infected+lung+cancer&rft.jtitle=Cancer+medicine+%28Malden%2C+MA%29&rft.au=Wu%2C+Liwei&rft.au=Chen%2C+Yongfang&rft.au=Wan%2C+Laiyi&rft.au=Wen%2C+Zilu&rft.date=2023-01-01&rft.pub=John+Wiley+and+Sons+Inc&rft.eissn=2045-7634&rft.volume=12&rft.issue=1&rft.spage=949&rft.epage=960&rft_id=info:doi/10.1002%2Fcam4.4853&rft_id=info%3Apmid%2F35608130&rft.externalDBID=PMC9844649 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-7634&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-7634&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-7634&client=summon |