Curative‐intent radiotherapy for pediatric osteosarcoma: The St. Jude experience

• Published in: Pediatric blood & cancer Vol. 66; no. 8; pp. e27763 - n/a
• Main Authors: Tinkle, Christopher L., Lu, Jason, Han, Yuanyuan, Li, Yimei, McCarville, Beth M., Neel, Michael D., Bishop, Michael W., Krasin, Matthew J.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2019
• Subjects: Adolescent; Adult; Background radiation; Bone cancer; Bone Neoplasms - pathology; Bone Neoplasms - radiotherapy; Brachytherapy - mortality; Chemotherapy; Child; curative intent; Female; Follow-Up Studies; Hematology; Humans; Male; Medical prognosis; Metastases; Morbidity; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - radiotherapy; Oncology; Osteosarcoma; Osteosarcoma - pathology; Osteosarcoma - radiotherapy; pediatric; Pediatrics; Population studies; Prognosis; Radiation; Radiation therapy; Regression analysis; Retrospective Studies; Sarcoma; Statistical models; Survival; Survival Rate; Toxic hazards; Toxicity; Young Adult; toxicity; curative intent; osteosarcoma; radiation therapy; pediatric

Background Radiation therapy (RT) confers local tumor control and survival advantages in some patients with osteosarcoma, yet pediatric and adolescent and young adult (AYA) population studies are limited. Methods Twenty‐eight patients treated with curative‐intent RT (median dose, 59.4 Gy; range, 40‐...