RNA editing‐mediated regulation of calcium‐dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission

• Published in: Journal of neurochemistry Vol. 158; no. 2; pp. 182 - 196
• Main Authors: Shumate, Kayla M., Tas, Sadik T., Kavalali, Ege T., Emeson, Ronald B.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.07.2021
• Subjects: ADAR; Adenosine; Adenosine Deaminase - metabolism; Animals; Calcium; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - physiology; CRISPR-Cas Systems; Editing; Electrophysiological Phenomena; GABA; gamma-Aminobutyric Acid - physiology; glutamate; Glutamatergic transmission; Glutamic Acid - physiology; Glycine; High-Throughput Nucleotide Sequencing; Hippocampus; Hippocampus - cytology; Hippocampus - metabolism; Isoforms; Localization; Mice; Mutation; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - physiology; Neuromodulation; Neuronal Plasticity - genetics; Neuronal Plasticity - physiology; Neurons; Neurotransmission; neurotransmitter; Neurotransmitter release; Neurotransmitters; Primary Cell Culture; Proteins; RNA editing; RNA Editing - genetics; RNA Editing - physiology; Secretion; SNAP receptors; Synapses; Synaptic depression; Synaptic plasticity; Synaptic transmission; Synaptic Transmission - genetics; Synaptic Transmission - physiology; Transcription; γ-Aminobutyric acid; GABA; ADAR; neurotransmitter; glutamate

Calcium‐dependent activator protein for secretion 1 (CAPS1) is a SNARE accessory protein that facilitates formation of the SNARE complex to enable neurotransmitter release. Messenger RNAs encoding CAPS1 are subject to a site‐specific adenosine‐to‐inosine (A‐to‐I) editing event resulting in a glutama...