Activation of Toll‐like receptor 7 signaling in labial salivary glands of primary Sjögren's syndrome patients

• Published in: Clinical and experimental immunology Vol. 196; no. 1; pp. 39 - 51
• Main Authors: Shimizu, T., Nakamura, H., Takatani, A., Umeda, M., Horai, Y., Kurushima, S., Michitsuji, T., Nakashima, Y., Kawakami, A.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.04.2019; John Wiley and Sons Inc
• Subjects: Aged; Cells, Cultured; Dendritic cells; Epithelial cells; Epithelial Cells - physiology; Female; Flow cytometry; Humans; Immunofluorescence; Immunohistochemistry; Innate immunity; Interferon; Interferon regulatory factor; Interferon regulatory factor 7; Interferon Regulatory Factor-7 - metabolism; Interferon-alpha - metabolism; Interferon-beta - metabolism; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Leukocytes (mononuclear); Lip - pathology; Lymphocytes B; Male; Middle Aged; MyD88 protein; Myeloid Differentiation Factor 88 - metabolism; Nuclear transport; Original; Peripheral blood; Plasma cells; plasmacytoid dendritic cells; Salivary gland; Salivary Glands - physiology; Sialadenitis - immunology; Signal Transduction; Sjogren's syndrome; Sjogren's Syndrome - immunology; Sjögren's syndrome; TLR7 protein; TLR‐7; Toll-Like Receptor 7 - metabolism; Toll-like receptors; TRAF6 protein; type I interferons; Western blotting; plasmacytoid dendritic cells; Sjögren's syndrome; TLR-7; type I interferons

Summary The aim of this study was to determine the expressions of Toll‐like receptors (TLRs) 7–9 and type I interferon (IFN) signal in labial salivary glands (LSGs) and cultured salivary gland epithelial cells (SGECs) from primary Sjögren's syndrome (pSS) patients. We performed an immunohistoch...