Mouth rinses efficacy on salivary SARS‐CoV‐2 viral load: A randomized clinical trial

Considering the global trend to confine the COVID‐19 pandemic by applying various preventive health measures, preprocedural mouth rinsing has been proposed to mitigate the transmission risk of SARS‐CoV‐2 in dental clinics. The study aimed to investigate the effect of different mouth rinses on saliva...

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Published inJournal of medical virology Vol. 95; no. 1; pp. e28412 - n/a
Main Authors Alzahrani, Manar M., Bamashmous, Shatha, Alkharobi, Hanaa, Alghamdi, Abdullah, Alharbi, Rahaf H., Hassan, Ahmed M., Darwish, Manar, Bukhari, Abdullah, Mahmoud, Ahmad Bakur, Alfaleh, Mohamed A., Mirza, Ahmed A., Abuzenadah, Adel M., Abujamel, Turki S., Hashem, Anwar M.
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.01.2023
John Wiley and Sons Inc
Subjects
Antiviral drugs
Cetylpyridinium - therapeutic use
Cetylpyridinium chloride
Chlorides
Clinical trials
coronavirus
COVID-19
Distilled water
Humans
Hydrogen Peroxide
Hypochlorous acid
Iodine
Mouth
Mouthwashes
Mouthwashes - therapeutic use
Pandemics
Povidone
Povidone-Iodine - therapeutic use
povidone‐iodine
Reverse transcription
Rinsing
saliva
SARS-CoV-2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
Viral diseases
Viral Load
Virology
Water
Water control
COVID-19
saliva
SARS-CoV-2
viral load
cetylpyridinium chloride
hydrogen peroxide
mouthwashes
coronavirus
povidone-iodine
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Abstract Considering the global trend to confine the COVID‐19 pandemic by applying various preventive health measures, preprocedural mouth rinsing has been proposed to mitigate the transmission risk of SARS‐CoV‐2 in dental clinics. The study aimed to investigate the effect of different mouth rinses on salivary viral load in COVID‐19 patients. This study was a single‐center, randomized, double‐blind, six‐parallel‐group, placebo‐controlled clinical trial that investigated the effect of four mouth rinses (1% povidone‐iodine, 1.5% hydrogen peroxide, 0.075% cetylpyridinium chloride, and 80 ppm hypochlorous acid) on salivary SARS‐CoV‐2 viral load relative to the distilled water and no‐rinse control groups. The viral load was measured by quantitative reverse transcription PCR (RT‐qPCR) at baseline and 5, 30, and 60 min post rinsing. The viral load pattern within each mouth rinse group showed a reduction overtime; however, this reduction was only statistically significant in the hydrogen peroxide group. Further, a significant reduction in the viral load was observed between povidone‐iodine, hydrogen peroxide, and cetylpyridinium chloride compared to the no‐rinse group at 60 min, indicating their late antiviral potential. Interestingly, a similar statistically significant reduction was also observed in the distilled water control group compared to the no‐rinse group at 60 min, proposing mechanical washing of the viral particles through the rinsing procedure. Therefore, results suggest using preprocedural mouth rinses, particularly hydrogen peroxide, as a risk‐mitigation step before dental procedures, along with strict adherence to other infection control measures.
AbstractList Considering the global trend to confine the COVID‐19 pandemic by applying various preventive health measures, preprocedural mouth rinsing has been proposed to mitigate the transmission risk of SARS‐CoV‐2 in dental clinics. The study aimed to investigate the effect of different mouth rinses on salivary viral load in COVID‐19 patients. This study was a single‐center, randomized, double‐blind, six‐parallel‐group, placebo‐controlled clinical trial that investigated the effect of four mouth rinses (1% povidone‐iodine, 1.5% hydrogen peroxide, 0.075% cetylpyridinium chloride, and 80 ppm hypochlorous acid) on salivary SARS‐CoV‐2 viral load relative to the distilled water and no‐rinse control groups. The viral load was measured by quantitative reverse transcription PCR (RT‐qPCR) at baseline and 5, 30, and 60 min post rinsing. The viral load pattern within each mouth rinse group showed a reduction overtime; however, this reduction was only statistically significant in the hydrogen peroxide group. Further, a significant reduction in the viral load was observed between povidone‐iodine, hydrogen peroxide, and cetylpyridinium chloride compared to the no‐rinse group at 60 min, indicating their late antiviral potential. Interestingly, a similar statistically significant reduction was also observed in the distilled water control group compared to the no‐rinse group at 60 min, proposing mechanical washing of the viral particles through the rinsing procedure. Therefore, results suggest using preprocedural mouth rinses, particularly hydrogen peroxide, as a risk‐mitigation step before dental procedures, along with strict adherence to other infection control measures.
Considering the global trend to confine the COVID-19 pandemic by applying various preventive health measures, preprocedural mouth rinsing has been proposed to mitigate the transmission risk of SARS-CoV-2 in dental clinics. The study aimed to investigate the effect of different mouth rinses on salivary viral load in COVID-19 patients. This study was a single-center, randomized, double-blind, six-parallel-group, placebo-controlled clinical trial that investigated the effect of four mouth rinses (1% povidone-iodine, 1.5% hydrogen peroxide, 0.075% cetylpyridinium chloride, and 80 ppm hypochlorous acid) on salivary SARS-CoV-2 viral load relative to the distilled water and no-rinse control groups. The viral load was measured by quantitative reverse transcription PCR (RT-qPCR) at baseline and 5, 30, and 60 min post rinsing. The viral load pattern within each mouth rinse group showed a reduction overtime; however, this reduction was only statistically significant in the hydrogen peroxide group. Further, a significant reduction in the viral load was observed between povidone-iodine, hydrogen peroxide, and cetylpyridinium chloride compared to the no-rinse group at 60 min, indicating their late antiviral potential. Interestingly, a similar statistically significant reduction was also observed in the distilled water control group compared to the no-rinse group at 60 min, proposing mechanical washing of the viral particles through the rinsing procedure. Therefore, results suggest using preprocedural mouth rinses, particularly hydrogen peroxide, as a risk-mitigation step before dental procedures, along with strict adherence to other infection control measures.
Considering the global trend to confine the COVID-19 pandemic by applying various preventive health measures, preprocedural mouth rinsing has been proposed to mitigate the transmission risk of SARS-CoV-2 in dental clinics. The study aimed to investigate the effect of different mouth rinses on salivary viral load in COVID-19 patients. This study was a single-center, randomized, double-blind, six-parallel-group, placebo-controlled clinical trial that investigated the effect of four mouth rinses (1% povidone-iodine, 1.5% hydrogen peroxide, 0.075% cetylpyridinium chloride, and 80 ppm hypochlorous acid) on salivary SARS-CoV-2 viral load relative to the distilled water and no-rinse control groups. The viral load was measured by quantitative reverse transcription PCR (RT-qPCR) at baseline and 5, 30, and 60 min post rinsing. The viral load pattern within each mouth rinse group showed a reduction overtime; however, this reduction was only statistically significant in the hydrogen peroxide group. Further, a significant reduction in the viral load was observed between povidone-iodine, hydrogen peroxide, and cetylpyridinium chloride compared to the no-rinse group at 60 min, indicating their late antiviral potential. Interestingly, a similar statistically significant reduction was also observed in the distilled water control group compared to the no-rinse group at 60 min, proposing mechanical washing of the viral particles through the rinsing procedure. Therefore, results suggest using preprocedural mouth rinses, particularly hydrogen peroxide, as a risk-mitigation step before dental procedures, along with strict adherence to other infection control measures.Considering the global trend to confine the COVID-19 pandemic by applying various preventive health measures, preprocedural mouth rinsing has been proposed to mitigate the transmission risk of SARS-CoV-2 in dental clinics. The study aimed to investigate the effect of different mouth rinses on salivary viral load in COVID-19 patients. This study was a single-center, randomized, double-blind, six-parallel-group, placebo-controlled clinical trial that investigated the effect of four mouth rinses (1% povidone-iodine, 1.5% hydrogen peroxide, 0.075% cetylpyridinium chloride, and 80 ppm hypochlorous acid) on salivary SARS-CoV-2 viral load relative to the distilled water and no-rinse control groups. The viral load was measured by quantitative reverse transcription PCR (RT-qPCR) at baseline and 5, 30, and 60 min post rinsing. The viral load pattern within each mouth rinse group showed a reduction overtime; however, this reduction was only statistically significant in the hydrogen peroxide group. Further, a significant reduction in the viral load was observed between povidone-iodine, hydrogen peroxide, and cetylpyridinium chloride compared to the no-rinse group at 60 min, indicating their late antiviral potential. Interestingly, a similar statistically significant reduction was also observed in the distilled water control group compared to the no-rinse group at 60 min, proposing mechanical washing of the viral particles through the rinsing procedure. Therefore, results suggest using preprocedural mouth rinses, particularly hydrogen peroxide, as a risk-mitigation step before dental procedures, along with strict adherence to other infection control measures.
Author Abuzenadah, Adel M.
Alkharobi, Hanaa
Bukhari, Abdullah
Mirza, Ahmed A.
Bamashmous, Shatha
Abujamel, Turki S.
Hassan, Ahmed M.
Hashem, Anwar M.
Alzahrani, Manar M.
Darwish, Manar
Mahmoud, Ahmad Bakur
Alharbi, Rahaf H.
Alfaleh, Mohamed A.
Alghamdi, Abdullah
AuthorAffiliation 6 Special Infectious Agents Unit, King Fahd Medical Research Center King Abdulaziz University Jeddah Saudi Arabia
8 College of Applied Medical Sciences Taibah University Almadinah Almunwarah Saudi Arabia
4 Ministry of Health Jeddah Saudi Arabia
7 Department of Medicine, Faculty of Medicine Imam Mohammed Ibn Saud Islamic University Riyadh Saudi Arabia
11 Department of Medical Microbiology and Parasitology, Faculty of Medicine King Abdulaziz University Jeddah Saudi Arabia
5 Vaccines and Immunotherapy Unit, King Fahd Medical Research Center King Abdulaziz University Jeddah Saudi Arabia
2 Department of Periodontology, Faculty of Dentistry King Abdulaziz University Jeddah Saudi Arabia
1 Department of Oral and Maxillofacial Prosthodontics, Faculty of Dentistry King Abdulaziz University Jeddah Saudi Arabia
9 Department of Pharmaceutics, Faculty of Pharmacy King Abdulaziz University Jeddah Saudi Arabia
3 Department of Oral Biology, Faculty of Dentistry King Abdulaziz University Jeddah Saudi Arabia
10 De
AuthorAffiliation_xml – name: 11 Department of Medical Microbiology and Parasitology, Faculty of Medicine King Abdulaziz University Jeddah Saudi Arabia
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Issue 1
Keywords COVID-19
saliva
SARS-CoV-2
viral load
cetylpyridinium chloride
hydrogen peroxide
mouthwashes
coronavirus
povidone-iodine
Language English
License Attribution-NonCommercial-NoDerivs
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Snippet Considering the global trend to confine the COVID‐19 pandemic by applying various preventive health measures, preprocedural mouth rinsing has been proposed to...
Considering the global trend to confine the COVID-19 pandemic by applying various preventive health measures, preprocedural mouth rinsing has been proposed to...
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StartPage e28412
SubjectTerms Antiviral drugs
Cetylpyridinium - therapeutic use
Cetylpyridinium chloride
Chlorides
Clinical trials
coronavirus
COVID-19
Distilled water
Humans
Hydrogen Peroxide
Hypochlorous acid
Iodine
Mouth
Mouthwashes
Mouthwashes - therapeutic use
Pandemics
Povidone
Povidone-Iodine - therapeutic use
povidone‐iodine
Reverse transcription
Rinsing
saliva
SARS-CoV-2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
Viral diseases
Viral Load
Virology
Water
Water control
Title Mouth rinses efficacy on salivary SARS‐CoV‐2 viral load: A randomized clinical trial
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjmv.28412
https://www.ncbi.nlm.nih.gov/pubmed/36527332
https://www.proquest.com/docview/2761189921
https://www.proquest.com/docview/2755579047
https://pubmed.ncbi.nlm.nih.gov/PMC9878137
Volume 95
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