Heavy metal ATPase 3 (HMA3) confers cadmium hypertolerance on the cadmium/zinc hyperaccumulator Sedum plumbizincicola

• Published in: The New phytologist Vol. 215; no. 2; pp. 687 - 698
• Main Authors: Liu, Huan, Zhao, Haixia, Wu, Longhua, Liu, Anna, Zhao, Fang‐Jie, Xu, Wenzhong
• Format: Journal Article
• Language: English
• Published: England New Phytologist Trust 01.07.2017; Wiley Subscription Services, Inc
• Subjects: Adenosine triphosphatase; Adenosine Triphosphatases - genetics; Adenosine Triphosphatases - metabolism; adenosinetriphosphatase; Cadmium; cadmium (Cd); Cadmium - pharmacokinetics; Cadmium - toxicity; Cloning, Molecular; Detoxification; Drug Resistance - drug effects; Drug Resistance - genetics; Ecotype; Ecotypes; Gene expression; Gene Expression Regulation, Plant; gene overexpression; genes; heavy metal ATPase 3 (HMA3); Heavy metals; heterologous gene expression; hyperaccumulator; hyperaccumulators; Leaves; Metals, Heavy - pharmacokinetics; Metals, Heavy - toxicity; Physiological functions; Plant Proteins - genetics; Plant Proteins - metabolism; Plant Shoots - drug effects; Plant Shoots - genetics; Plant Shoots - metabolism; Plant species; Plants, Genetically Modified; Rare species; RNA Interference; RNA-mediated interference; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Sedum - drug effects; Sedum - genetics; Sedum - metabolism; Sedum plubizincicola; Sedum plumbizincicola; Shoots; Soil; Soil contamination; Soil pollution; Tissue Distribution; tissues; tolerance; tonoplast; Toxicity; transgenic plants; transporter; vacuole; Zinc; Zinc - pharmacokinetics; Zinc - toxicity; transgenic plants; Sedum plubizincicola; hyperaccumulator; vacuole; transporter; heavy metal ATPase 3 (HMA3); tolerance; cadmium (Cd)

Cadmium (Cd) is highly toxic to most organisms, but some rare plant species can hyperaccumulate Cd in aboveground tissues without suffering from toxicity. The mechanism underlying Cd detoxification by hyperaccumulators is interesting but unclear. Here, the heavy metal ATPase 3 (SpHMA3) gene responsi...