Ablation of cytoskeletal scaffolding proteins, Band 4.1B and Whirlin, leads to cerebellar purkinje axon pathology and motor dysfunction

• Published in: Journal of neuroscience research Vol. 97; no. 3; pp. 313 - 331
• Main Authors: Saifetiarova, Julia, Bhat, Manzoor A.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2019
• Subjects: Ablation; axonal degeneration; Axonal transport; Axons; Band 4.1B; Brain; Cerebellum; Cytoskeleton; Domains; Electrical properties; Gait; Gait recognition; Localization; Locomotor activity; Motor ability; motor coordination; Motor skill learning; Motors; myelinated axons; Nerves; Neurons; Organelles; Preservation; Proteins; Purkinje cells; Purkinje neurons; Scaffolding; Spinal cord; Ultrastructure; whirlin; Band 4.1B; myelinated axons; axonal degeneration; whirlin; cerebellum; motor coordination; Purkinje neurons

The cerebellar cortex receives neural information from other brain regions to allow fine motor coordination and motor learning. The primary output neurons from the cerebellum are the Purkinje neurons that transmit inhibitory responses to deep cerebellar nuclei through their myelinated axons. Altered...