Preliminary report on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Spike mutation T478K

• Published in: Journal of medical virology Vol. 93; no. 9; pp. 5638 - 5643
• Main Authors: Di Giacomo, Simone, Mercatelli, Daniele, Rakhimov, Amir, Giorgi, Federico M.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2021; John Wiley and Sons Inc
• Subjects: ACE2; Amino acid sequence; Amino acids; Angiotensin-converting enzyme 2; Containment; Coronaviruses; COVID-19; COVID-19 - virology; Drug efficacy; Electrostatic properties; Europe; Genome, Viral; genomic surveillance; Humans; Mexico; Mutation; Phylogeny; Proteins; Receptors; Repositories; Respiratory diseases; S:T478K; SARS-CoV-2 - genetics; SARS‐CoV‐2; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Short Communication; Spike; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - physiology; Spike protein; Spike:T478K; T478K; United States; Vaccines; Viral diseases; Virology; United States; Mexico; Europe; COVID-19; Spike; SARS-CoV-2; T478K; S:T478K; Spike:T478K; genomic surveillance

Several severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants have emerged, posing a renewed threat to coronavirus disease 2019 containment and to vaccine and drug efficacy. In this study, we analyzed more than 1,000,000 SARS‐CoV‐2 genomic sequences deposited up to April 27, 2021, on...