RNA localization regulates diverse and dynamic cellular processes

• Published in: Traffic (Copenhagen, Denmark) Vol. 19; no. 7; pp. 496 - 502
• Main Authors: Ryder, Pearl V., Lerit, Dorothy A.
• Format: Journal Article
• Language: English
• Published: Former Munksgaard John Wiley & Sons A/S 01.07.2018; Wiley Subscription Services, Inc
• Subjects: Animals; Axonal Transport; centrosomes; Cytoskeleton; Embryos; endoplasmic reticulum; focal adhesions; Gene regulation; Humans; Localization; mitochondria; Neurogenesis; Neurons - metabolism; Organelles; Pattern formation; RNA localization; RNA, Messenger - metabolism; RNA‐binding proteins; Transcription; translational control; focal adhesions; mitochondria; centrosomes; RNA localization; RNA-binding proteins; translational control; endoplasmic reticulum

RNA localization is a fundamental paradigm used to compartmentalize gene activity within diverse cellular contexts. When coupled to translational control, the localization of messenger RNA (mRNA) generates localized protein enrichments within cells. Long appreciated for its role in neurogenesis and...