A Double-Blind, Randomized Multicenter Trial Comparing Duloxetine with Placebo in the Management of Diabetic Peripheral Neuropathic Pain

• Published in: Pain medicine (Malden, Mass.) Vol. 6; no. 5; pp. 346 - 356
• Main Authors: Raskin, Joel, Pritchett, Yili L., Wang, Fujun, D'Souza, Deborah N., Waninger, Amy L., Iyengar, Smriti, Wernicke, Joachim F.
• Format: Journal Article
• Language: English
• Published: Oxford, UK and Malden, USA Blackwell Science Inc 01.09.2005
• Subjects: Aged; Antidepressant; Diabetic Neuropathies - drug therapy; Diabetic Neuropathy; Double-Blind Method; Duloxetine; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Norepinephrine; Pain; Patient Selection; Placebos; Serotonin; Serotonin Uptake Inhibitors - administration & dosage; Serotonin Uptake Inhibitors - adverse effects; Thiophenes - administration & dosage; Thiophenes - adverse effects; Treatment Outcome

ABSTRACT Objective.  Assess efficacy and safety of duloxetine, a selective serotonin and norepinephrine reuptake inhibitor, on the reduction of pain severity, in patients with diabetic peripheral neuropathic pain (DPNP). Methods.  This was a multicenter, parallel, double‐blind, randomized, placebo‐c...