A Large‐scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma

• Published in: Hepatology (Baltimore, Md.) Vol. 67; no. 2; pp. 662 - 675
• Main Authors: Luo, Ping, Yin, Peiyuan, Hua, Rui, Tan, Yexiong, Li, Zaifang, Qiu, Gaokun, Yin, Zhenyu, Xie, Xingwang, Wang, Xiaomei, Chen, Wenbin, Zhou, Lina, Wang, Xiaolin, Li, Yanli, Chen, Hongsong, Gao, Ling, Lu, Xin, Wu, Tangchun, Wang, Hongyang, Niu, Junqi, Xu, Guowang
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.02.2018; John Wiley and Sons Inc
• Subjects: Adult; Aged; alpha-Fetoproteins - analysis; Bile Acids and Salts - blood; Biomarkers; Biomarkers, Tumor - blood; Carcinoma, Hepatocellular - blood; Carcinoma, Hepatocellular - diagnosis; Chronic infection; Cirrhosis; Diagnosis; Early Detection of Cancer; Female; Hepatitis B; Hepatocellular carcinoma; Hepatology; Humans; Interferon; Liquid chromatography; Liver cancer; Liver cirrhosis; Liver Neoplasms - blood; Liver Neoplasms - diagnosis; Male; Mass spectroscopy; Metabolomics; Middle Aged; Original; Tryptophan

Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. The lack of effective biomarkers for the early detection of HCC results in unsatisfactory curative treatments. Here, metabolite biomarkers were identified and validated for HCC diagnosis. A total of 1,448 subjects, including h...