Diabetes and cancer risk: A Mendelian randomization study

• Published in: International journal of cancer Vol. 146; no. 3; pp. 712 - 719
• Main Authors: Goto, Atsushi, Yamaji, Taiki, Sawada, Norie, Momozawa, Yukihide, Kamatani, Yoichiro, Kubo, Michiaki, Shimazu, Taichi, Inoue, Manami, Noda, Mitsuhiko, Tsugane, Shoichiro, Iwasaki, Motoki
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.02.2020; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Body Mass Index; Cancer; Cancer Epidemiology; Case-Control Studies; Colorectal cancer; Colorectal carcinoma; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; epidemiology; Follow-Up Studies; genetics; Genome-wide association studies; Genome-Wide Association Study; Genomes; Health risk assessment; Humans; Incidence; Japan - epidemiology; Medical research; Mendelian randomization; Mendelian Randomization Analysis; Middle Aged; Neoplasms - epidemiology; Neoplasms - genetics; Pancreas; Polymorphism, Single Nucleotide; Prospective Studies; Public health; Regression analysis; Risk Assessment - methods; Risk Factors; Japan; epidemiology; genetics; Mendelian randomization; diabetes

Earlier cohort studies using conventional regression models have consistently shown an increased cancer risk among individuals with type 2 diabetes. However, reverse causality and residual confounding due to common risk factors could exist, and it remains unclear whether diabetes per se contributes...