High‐resolution analysis of individual spike peptide‐specific CD4+ T‐cell responses in vaccine recipients and COVID‐19 patients

• Published in: Clinical & translational immunology Vol. 11; no. 8; pp. e1410 - n/a
• Main Authors: Karsten, Hendrik, Cords, Leon, Westphal, Tim, Knapp, Maximilian, Brehm, Thomas Theo, Hermanussen, Lennart, Omansen, Till Frederik, Schmiedel, Stefan, Woost, Robin, Ditt, Vanessa, Peine, Sven, Lütgehetmann, Marc, Huber, Samuel, Ackermann, Christin, Wittner, Melanie, Addo, Marylyn Martina, Sette, Alessandro, Sidney, John, Schulze zur Wiesch, Julian
• Format: Journal Article
• Language: English
• Published: Australia John Wiley & Sons, Inc 2022; John Wiley and Sons Inc; Wiley
• Subjects: Antibodies; B.1.1.529; CD4 antigen; CD4+ T cells; Coronaviruses; COVID-19; COVID-19 vaccines; Cytokines; Drb1 protein; Enzyme-linked immunosorbent assay; Glycoproteins; Histocompatibility antigen HLA; Infections; Interferon; Lymphocytes; MHC class II; Original; Patients; Peptides; SARS‐CoV‐2; Severe acute respiratory syndrome coronavirus 2; Spike glycoprotein; spike protein; Vaccination; vaccines; CD4+ T cells; MHC class II; B.1.1.529; SARS‐CoV‐2; vaccines; spike protein
• ISSN: 2050-0068; 2050-0068
• DOI: 10.1002/cti2.1410

Objectives Potential differences in the breadth, distribution and magnitude of CD4+ T‐cell responses directed against the SARS‐CoV‐2 spike glycoprotein between vaccinees, COVID‐19 patients and subjects who experienced both ways of immunisation have not been comprehensively compared on a peptide leve...