Dosage Regimens for Meropenem in Children with Pseudomonas Infections Do Not Meet Serum Concentration Targets

• Published in: Clinical and translational science Vol. 13; no. 2; pp. 301 - 308
• Main Authors: Hassan, Hazem E., Ivaturi, Vijay, Gobburu, Jogarao, Green, Thomas P.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.03.2020; John Wiley and Sons Inc; Wiley
• Subjects: Abdomen; Age; Antibiotics; Children; Creatinine; Datasets; Dosage; Drug dosages; Gestational age; Infants; Infections; Meropenem; Minimum inhibitory concentration; Pathogens; Pediatrics; Pharmacokinetics; Population; Studies; Therapeutic applications; United States > US

There have been literature reports that some recommended meropenem dosage regimens may fail to meet therapeutic targets in some high‐risk children and adults. We evaluated this observation in children using literature studies conducted in infants and children. Observed and, as necessary, simulated d...