Comprehensive comparison between 222 CTLA‐4 haploinsufficiency and 212 LRBA deficiency patients: a systematic review

• Published in: Clinical and experimental immunology Vol. 205; no. 1; pp. 28 - 43
• Main Authors: Jamee, M., Hosseinzadeh, S., Sharifinejad, N., Zaki‐Dizaji, M., Matloubi, M., Hasani, M., Baris, S., Alsabbagh, M., Lo, B., Azizi, G.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.07.2021; John Wiley and Sons Inc
• Subjects: Atopy; CD9 antigen; CHAI; CTLA‐4; Cytotoxicity; Haploinsufficiency; Immunoglobulin A; Immunosuppressive agents; inborn errors of immunity; LATAIE; Lipopolysaccharides; LRBA; Lymphocytes B; Lymphocytes T; Natural killer cells; Neurological diseases; Patients; primary immunodeficiency disease; Review; Reviews; Rituximab; Serum levels; Transplantation; primary immunodeficiency disease; CHAI; CTLA-4; inborn errors of immunity; LATAIE; LRBA

Summary Cytotoxic T lymphocyte antigen 4 (CTLA‐4) haploinsufficiency (CHAI) and lipopolysaccharide‐responsive beige‐like anchor (LRBA) deficiency (LATAIE) are newly identified inborn errors of immunity with shared molecular pathomechanisms and clinical manifestations. In this review, we aimed to pro...