The role of thromboxane prostanoid receptor signaling in gastric ulcer healing

• Published in: International journal of experimental pathology Vol. 103; no. 1; pp. 4 - 12
• Main Authors: Yamane, Sakiko, Amano, Hideki, Ito, Yoshiya, Betto, Tomohiro, Matsui, Yoshio, Koizumi, Wasaburo, Narumiya, Shuh, Majima, Masataka
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.02.2022; John Wiley and Sons Inc
• Subjects: Angiogenesis; Animals; Bone marrow; Bone marrow transplantation; Cell migration; gastric ulcer healing; Growth factors; Healing; Immunofluorescence; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic - metabolism; Original; Platelet Activation - drug effects; Platelets; Prostaglandins - pharmacology; Receptors; Receptors, Thromboxane - drug effects; Rodents; Signal Transduction - drug effects; Signaling; Stomach Ulcer - drug therapy; Stomach Ulcer - metabolism; TGF‐β; Thromboxane A2; Thromboxanes - pharmacology; Transforming growth factor-b; TXA2; Ulcers; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; VEGF‐A; Wound Healing - drug effects; TGF-β; TXA2; gastric ulcer healing; VEGF-A; angiogenesis

The process of gastric ulcer healing includes cell migration, proliferation, angiogenesis and re‐epithelialization. Platelets contain angiogenesis stimulating factors that induce angiogenesis. Thromboxane A2 (TXA2) not only induces platelet activity but also angiogenesis. This study investigated the...