Muscle spindle reinnervation using transplanted embryonic dorsal root ganglion cells after peripheral nerve transection in rats

• Published in: Cell proliferation Vol. 52; no. 5; pp. e12660 - n/a
• Main Authors: Asano, Kenichi, Nakano, Tomonori, Tokutake, Katsuhiro, Ishii, Hisao, Nishizuka, Takanobu, Iwatsuki, Katsuyuki, Onishi, Tetsuro, Kurimoto, Shigeru, Yamamoto, Michiro, Tatebe, Masahiro, Hirata, Hitoshi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.09.2019; John Wiley and Sons Inc
• Subjects: Animals; Antibodies; Calbindin-D28K; Calbindins - metabolism; Cells; Denervation; Dorsal root ganglia; Embryo, Mammalian - cytology; Embryos; Ganglia, Spinal - cytology; Ganglia, Spinal - metabolism; Ganglia, Spinal - transplantation; Ganglion cells; Immunoreactivity; Male; Muscle spindles; Muscle Spindles - metabolism; Muscles; Musculoskeletal system; Nerve Fibers - physiology; Neurons; Original; Peripheral Nerve Injuries - therapy; Peripheral nerves; Proprioception; Proteins; Rats; Rats, Inbred F344; Regeneration; Reinnervation; Sciatic nerve; Sensory neurons; Skeletal muscle; Statistical analysis; Tibial Nerve - metabolism; Tibial Nerve - pathology; Transplantation; Japan

Objectives Muscle spindles are proprioceptive receptors in the skeletal muscle. Peripheral nerve injury results in a decreased number of muscle spindles and their morphologic deterioration. However, the muscle spindles recover when skeletal muscles are reinnervated with surgical procedures, such as...