Decreased Interleukin‐20 Expression in Scleroderma Skin Contributes to Cutaneous Fibrosis

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 66; no. 6; pp. 1636 - 1647
• Main Authors: Kudo, Hideo, Jinnin, Masatoshi, Asano, Yoshihide, Trojanowska, Maria, Nakayama, Wakana, Inoue, Kuniko, Honda, Noritoshi, Kajihara, Ikko, Makino, Katsunari, Fukushima, Satoshi, Ihn, Hironobu
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2014
• Subjects: Adult; Aged; Aged, 80 and over; Animals; Antigens, CD - metabolism; Bleomycin - adverse effects; Case-Control Studies; Cells, Cultured; Collagen; Collagen Type I - metabolism; Cytokines; Disease Models, Animal; Endoglin; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; Extracellular Matrix - pathology; Female; Fibroblasts; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibroblasts - pathology; Fibrosis - chemically induced; Fibrosis - pathology; Gene expression; Humans; Interleukins - metabolism; Interleukins - pharmacology; Male; Mice; Mice, Inbred BALB C; Middle Aged; Phenotype; Receptors, Cell Surface - metabolism; Scleroderma; Scleroderma, Diffuse - metabolism; Scleroderma, Diffuse - pathology; Scleroderma, Limited - metabolism; Scleroderma, Limited - pathology; Signal Transduction - physiology; Skin - metabolism; Skin - pathology; Smad3 Protein - metabolism
• ISSN: 2326-5191; 2326-5205; 2326-5205
• DOI: 10.1002/art.38380

Objective To clarify the role of interleukin‐20 (IL‐20) in the regulatory mechanism of extracellular matrix expression and to determine the contribution of IL‐20 to the phenotype of systemic sclerosis (SSc). Methods Protein and messenger RNA (mRNA) levels of collagen, Fli‐1, IL‐20, and IL‐20 recepto...