Relaxin and insulin‐like peptide 3 in the musculoskeletal system: from bench to bedside

• Published in: British journal of pharmacology Vol. 174; no. 10; pp. 1015 - 1024
• Main Authors: Ferlin, Alberto, De Toni, Luca, Sandri, Marco, Foresta, Carlo
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2017; John Wiley and Sons Inc
• Subjects: Androgens; Animal models; Animals; Bone and Bones - cytology; Bone and Bones - metabolism; Bone growth; Bone healing; Bone mass; Bone remodeling; Bone resorption; Fetuses; Fibrosis; Gender; Hormones; Humans; Insulin; Insulin - metabolism; Leydig cells; Ligaments; Muscle, Skeletal - metabolism; Muscles; Musculoskeletal system; Osteogenesis; Osteoporosis; Peptides; Pregnancy; Prostate; Proteins - metabolism; Regeneration; Relaxin; Relaxin - metabolism; Review; Sarcopenia; Sex differences; Sex hormones; Skeletal muscle; Themed Section: Review

Skeletal muscles and bones form a joined functional unit sharing a complex mechanical, biochemical and hormonal crosstalk. A number of factors, including sex hormones, physiologically regulate the musculoskeletal system. Striking gender differences in muscle and bone mass, and function are mainly ca...