DNMT3L inhibits hepatocellular carcinoma progression through DNA methylation of CDO1: insights from big data to basic research

• Published in: Journal of translational medicine Vol. 22; no. 1; pp. 128 - 15
• Main Authors: Yan, Xiaokai, Qi, Yao, Yao, Xinyue, Zhou, Nanjing, Ye, Xinxin, Chen, Xing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.02.2024; BioMed Central; BMC
• Subjects: Apoptosis; Big Data; Bioinformatics; Cancer therapies; Care and treatment; CDO1; Cell cycle; Cell proliferation; Data analysis; Development and progression; Diagnosis; DNA methylation; DNMT3L; Genes; Genetic aspects; Health aspects; Hepatocellular carcinoma; Hepatoma; Laboratory animals; Life sciences; Liver cancer; Medical prognosis; Medical research; Metastases; Metastasis; Methylation; Phenotypes; Proteins; Risk factors; Transcriptomics; Tumors; China; Beijing China; United Kingdom > UK; United States > US; Germany; DNA methylation; Hepatocellular carcinoma; DNMT3L; Big data; CDO1

DNMT3L is a crucial DNA methylation regulatory factor, yet its function and mechanism in hepatocellular carcinoma (HCC) remain poorly understood. Bioinformatics-based big data analysis has increasingly gained significance in cancer research. Therefore, this study aims to elucidate the role of DNMT3L...