Estimation of tumor control probability model parameters from 3-D dose distributions of non-small cell lung cancer patients

• Published in: Lung cancer (Amsterdam, Netherlands) Vol. 24; no. 1; pp. 31 - 37
• Main Authors: Martel, Mary Kaye, Ten Haken, Randall K, Hazuka, Mark B, Kessler, Marc L, Strawderman, Myla, Turrisi, Andrew T, Lawrence, Theodore S, Fraass, Benedick A, Lichter, Allen S
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.04.1999; Elsevier Science
• Subjects: Biological and medical sciences; Carcinoma, Non-Small-Cell Lung - radiotherapy; Disease-Free Survival; Diseases of the respiratory system; Dose-Response Relationship, Radiation; Dose–volume histogram; Humans; Local control; Lung Neoplasms - radiotherapy; Medical sciences; Models, Theoretical; Non-small cell lung cancer; Radiation Dosage; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Retrospective Studies; Three-dimensional treatment planning; Tumor control probability; Three-dimensional treatment planning; Tumor control probability; Local control; Dose–volume histogram; Non-small cell lung cancer; Dose repartition; Lung disease; Histogram; Respiratory disease; Malignant tumor; Three dimensional field; Radiotherapy; Bronchopulmonary; Dose activity relation; Treatment; Bronchus disease; Mathematical model; Response probability; Non small cell carcinoma

Tumor control probability (TCP) model calculations may be used in a relative manner to evaluate and optimize three-dimensional (3-D) treatment plans. Using a mathematical model which makes a number of simplistic assumptions, TCPs can be estimated from a 3-D dose distribution of the tumor given the d...