PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

• Published in: Nature communications Vol. 5; no. 1; p. 4436
• Main Authors: Yang, Liangchun, Xie, Min, Yang, Minghua, Yu, Yan, Zhu, Shan, Hou, Wen, Kang, Rui, Lotze, Michael T., Billiar, Timothy R., Wang, Haichao, Cao, Lizhi, Tang, Daolin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.07.2014; Nature Publishing Group
• Subjects: 13/21; 13/89; 631/250/256/1980; 631/443/319; 692/420/2780; 82/29; Animals; Blotting, Western; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Line; Endotoxemia - genetics; Endotoxemia - metabolism; Glycolysis - genetics; Glycolysis - physiology; HMGB1 Protein - genetics; HMGB1 Protein - metabolism; Humanities and Social Sciences; Hypoxia; Immunoprecipitation; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred BALB C; multidisciplinary; Oxidative Phosphorylation; Science; Science (multidisciplinary); Sepsis - genetics; Sepsis - metabolism; Thyroid Hormone-Binding Proteins; Thyroid Hormones - genetics; Thyroid Hormones - metabolism

Increasing evidence suggests the important role of metabolic reprogramming in the regulation of the innate inflammatory response, but the underlying mechanism remains unclear. Here we provide evidence to support a novel role for the pyruvate kinase M2 (PKM2)-mediated Warburg effect, namely aerobic g...